Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isola...

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Autores principales:	Lorraine Southam, Arthur Gilly, Dániel Süveges, Aliki-Eleni Farmaki, Jeremy Schwartzentruber, Ioanna Tachmazidou, Angela Matchan, Nigel W. Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, Yali Xue, George Dedoussis, Eleftheria Zeggini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3b1f1065eac445cb9cf66847168b057
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spelling	oai:doaj.org-article:e3b1f1065eac445cb9cf66847168b0572021-12-02T17:01:17ZWhole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits10.1038/ncomms156062041-1723https://doaj.org/article/e3b1f1065eac445cb9cf66847168b0572017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15606https://doaj.org/toc/2041-1723Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populationsLorraine SouthamArthur GillyDániel SüvegesAliki-Eleni FarmakiJeremy SchwartzentruberIoanna TachmazidouAngela MatchanNigel W. RaynerEmmanouil TsafantakisMaria KaraleftheriYali XueGeorge DedoussisEleftheria ZegginiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorraine Southam Arthur Gilly Dániel Süveges Aliki-Eleni Farmaki Jeremy Schwartzentruber Ioanna Tachmazidou Angela Matchan Nigel W. Rayner Emmanouil Tsafantakis Maria Karaleftheri Yali Xue George Dedoussis Eleftheria Zeggini Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
description	Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populations
format	article
author	Lorraine Southam Arthur Gilly Dániel Süveges Aliki-Eleni Farmaki Jeremy Schwartzentruber Ioanna Tachmazidou Angela Matchan Nigel W. Rayner Emmanouil Tsafantakis Maria Karaleftheri Yali Xue George Dedoussis Eleftheria Zeggini
author_facet	Lorraine Southam Arthur Gilly Dániel Süveges Aliki-Eleni Farmaki Jeremy Schwartzentruber Ioanna Tachmazidou Angela Matchan Nigel W. Rayner Emmanouil Tsafantakis Maria Karaleftheri Yali Xue George Dedoussis Eleftheria Zeggini
author_sort	Lorraine Southam
title	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_short	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_full	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_fullStr	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_full_unstemmed	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_sort	whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3b1f1065eac445cb9cf66847168b057
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Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

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