The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.

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While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliomas also exhibit high levels of copy number alterat...

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Bibliographic Details
Main Authors: Irena Bočkaj, Tosca E I Martini, Eduardo S de Camargo Magalhães, Petra L Bakker, Tiny G J Meeuwsen-de Boer, Inna Armandari, Saskia L Meuleman, Marin T Mondria, Colin Stok, Yannick P Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J C Broekhuis, Hilda van den Bos, Diana C J Spierings, Femke C A Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A T M van Vugt, Floris Foijer, Sophia W M Bruggeman
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Genetics
QH426-470
Online Access:https://doaj.org/article/e3b40f56962c48b392b15bc0a11a6d55
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