Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study

Hanan Al Rayes,1 Sultana Abdulaziz,2 Asma Mohammed Alotaibi,3 Mufaddal Adil Alaithan,1 Mohammed Attar,4 Hassan Daghasi,4 Rand Melibari,2 Ali H Althagafi,4 Basant Elnady4,5 1Rheumatology Division, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Division of Rheumato...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Al Rayes H, Abdulaziz S, Alotaibi AM, Alaithan MA, Attar M, Daghasi H, Melibari R, Althagafi AH, Elnady B
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
Acceso en línea:https://doaj.org/article/e3b472ede44c4d2ba2c44e051a8264e4
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e3b472ede44c4d2ba2c44e051a8264e4
record_format dspace
spelling oai:doaj.org-article:e3b472ede44c4d2ba2c44e051a8264e42021-12-02T17:40:54ZAdverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study1179-156Xhttps://doaj.org/article/e3b472ede44c4d2ba2c44e051a8264e42021-06-01T00:00:00Zhttps://www.dovepress.com/adverse-impact-of-rheumatoid-arthritis-on-pregnancy-outcomes-a-saudi-a-peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XHanan Al Rayes,1 Sultana Abdulaziz,2 Asma Mohammed Alotaibi,3 Mufaddal Adil Alaithan,1 Mohammed Attar,4 Hassan Daghasi,4 Rand Melibari,2 Ali H Althagafi,4 Basant Elnady4,5 1Rheumatology Division, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Division of Rheumatology, Department of Medicine, King Fahad Hospital, Jeddah, Saudi Arabia; 3Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 4Division of Rheumatology, Department of Medicine, Al Hada Armed Forces Hospital, Taif, Saudi Arabia; 5Rheumatology, Rehabilitation and Physical Medicine Department, Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Basant ElnadyDivision of Rheumatology, Department of Medicine, Al Hada Armed Forces Hospital, Al Hada Ring Road, Al Hada, Postal Code 1347, Taif, Zip Code 21944, Saudi ArabiaTel +966562387723Fax +966127542811Email basantelnady@gmail.comBackground: Rheumatoid arthritis (RA) is associated with adverse pregnancy outcomes and postpartum complications, especially with severe disease activity.Objective: The current study aimed to compare the pregnancy outcomes in patients with RA and healthy controls as well as to assess the impact of disease-related variables, medications and disease activity on pregnancy and neonatal-related outcomes in the Saudi population.Methods: This prospective multicenter study included pregnant female patients with RA from three tertiary centers in Saudi Arabia. The demographics, disease activity scoring (DAS28-CRP), medication before and during pregnancy, pregnancy-related outcomes, and complications in comparison to age-matched healthy female controls were noted.Results: A total of 77 pregnant patients with RA and 250 healthy age-matched pregnant controls were included in the study. A total of 67.53% were in remission before conception (DAS28CRP ≤ 2.6), and 81.8% of pregnancies were planned. Age of conception, preterm labor, neonatal intensive care unit (NICU) admission and low birth weight were statistically significant (p < 0.05) and higher in RA patients than in healthy controls. Longer disease duration (p < 0.001), and high C-reactive protein and erythrocyte sedimentation rate levels before conception (p ≤ 0.001) were statistically associated with preterm NICU admission. There was statistically significant association between mild (p = 0.015) or moderate to severe DAS28-CRP (p = 0.001) and RA patients regarding pregnancy outcomes. The classification table obtained from the logistic model showed patients with mild and moderate-severe DAS28-CRP have significantly high chances of having an adverse pregnancy outcome.Conclusion: RA has a negative impact on pregnancy-related outcomes. Higher disease activity is considered a major risk; thus, tight disease control should be aimed. Planned pregnancy follow-up is associated with better pregnancy outcomes.Keywords: rheumatoid arthritis, pregnancy, disease activityAl Rayes HAbdulaziz SAlotaibi AMAlaithan MAAttar MDaghasi HMelibari RAlthagafi AHElnady BDove Medical Pressarticlerheumatoid arthritispregnancydisease activityDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 167-175 (2021)
institution DOAJ
collection DOAJ
language EN
topic rheumatoid arthritis
pregnancy
disease activity
Diseases of the musculoskeletal system
RC925-935
spellingShingle rheumatoid arthritis
pregnancy
disease activity
Diseases of the musculoskeletal system
RC925-935
Al Rayes H
Abdulaziz S
Alotaibi AM
Alaithan MA
Attar M
Daghasi H
Melibari R
Althagafi AH
Elnady B
Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
description Hanan Al Rayes,1 Sultana Abdulaziz,2 Asma Mohammed Alotaibi,3 Mufaddal Adil Alaithan,1 Mohammed Attar,4 Hassan Daghasi,4 Rand Melibari,2 Ali H Althagafi,4 Basant Elnady4,5 1Rheumatology Division, Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Division of Rheumatology, Department of Medicine, King Fahad Hospital, Jeddah, Saudi Arabia; 3Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 4Division of Rheumatology, Department of Medicine, Al Hada Armed Forces Hospital, Taif, Saudi Arabia; 5Rheumatology, Rehabilitation and Physical Medicine Department, Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Basant ElnadyDivision of Rheumatology, Department of Medicine, Al Hada Armed Forces Hospital, Al Hada Ring Road, Al Hada, Postal Code 1347, Taif, Zip Code 21944, Saudi ArabiaTel +966562387723Fax +966127542811Email basantelnady@gmail.comBackground: Rheumatoid arthritis (RA) is associated with adverse pregnancy outcomes and postpartum complications, especially with severe disease activity.Objective: The current study aimed to compare the pregnancy outcomes in patients with RA and healthy controls as well as to assess the impact of disease-related variables, medications and disease activity on pregnancy and neonatal-related outcomes in the Saudi population.Methods: This prospective multicenter study included pregnant female patients with RA from three tertiary centers in Saudi Arabia. The demographics, disease activity scoring (DAS28-CRP), medication before and during pregnancy, pregnancy-related outcomes, and complications in comparison to age-matched healthy female controls were noted.Results: A total of 77 pregnant patients with RA and 250 healthy age-matched pregnant controls were included in the study. A total of 67.53% were in remission before conception (DAS28CRP ≤ 2.6), and 81.8% of pregnancies were planned. Age of conception, preterm labor, neonatal intensive care unit (NICU) admission and low birth weight were statistically significant (p < 0.05) and higher in RA patients than in healthy controls. Longer disease duration (p < 0.001), and high C-reactive protein and erythrocyte sedimentation rate levels before conception (p ≤ 0.001) were statistically associated with preterm NICU admission. There was statistically significant association between mild (p = 0.015) or moderate to severe DAS28-CRP (p = 0.001) and RA patients regarding pregnancy outcomes. The classification table obtained from the logistic model showed patients with mild and moderate-severe DAS28-CRP have significantly high chances of having an adverse pregnancy outcome.Conclusion: RA has a negative impact on pregnancy-related outcomes. Higher disease activity is considered a major risk; thus, tight disease control should be aimed. Planned pregnancy follow-up is associated with better pregnancy outcomes.Keywords: rheumatoid arthritis, pregnancy, disease activity
format article
author Al Rayes H
Abdulaziz S
Alotaibi AM
Alaithan MA
Attar M
Daghasi H
Melibari R
Althagafi AH
Elnady B
author_facet Al Rayes H
Abdulaziz S
Alotaibi AM
Alaithan MA
Attar M
Daghasi H
Melibari R
Althagafi AH
Elnady B
author_sort Al Rayes H
title Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
title_short Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
title_full Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
title_fullStr Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
title_full_unstemmed Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study
title_sort adverse impact of rheumatoid arthritis on pregnancy outcomes: a saudi arabia prospective multicenter study
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/e3b472ede44c4d2ba2c44e051a8264e4
work_keys_str_mv AT alrayesh adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT abdulazizs adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT alotaibiam adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT alaithanma adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT attarm adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT daghasih adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT melibarir adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT althagafiah adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
AT elnadyb adverseimpactofrheumatoidarthritisonpregnancyoutcomesasaudiarabiaprospectivemulticenterstudy
_version_ 1718379733168685056