Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution

Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics and a mass spectrometry workflow to analyze tissue...

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Detalles Bibliográficos
Autores principales: Paul D. Piehowski, Ying Zhu, Lisa M. Bramer, Kelly G. Stratton, Rui Zhao, Daniel J. Orton, Ronald J. Moore, Jia Yuan, Hugh D. Mitchell, Yuqian Gao, Bobbie-Jo M. Webb-Robertson, Sudhansu K. Dey, Ryan T. Kelly, Kristin E. Burnum-Johnson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e3b5a3a1d7b147dd83097e22370e56dc
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Sumario:Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics and a mass spectrometry workflow to analyze tissue voxels, generating quantitative cell-type-specific images.