Associations between SNPs and immune-related circulating proteins in schizophrenia

Abstract Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking f...

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Autores principales:	Man K. Chan, Jason D. Cooper, Stefanie Heilmann-Heimbach, Josef Frank, Stephanie H. Witt, Markus M. Nöthen, Johann Steiner, Marcella Rietschel, Sabine Bahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3ba237d1f564901811d13305024db73
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spelling	oai:doaj.org-article:e3ba237d1f564901811d13305024db732021-12-02T15:05:28ZAssociations between SNPs and immune-related circulating proteins in schizophrenia10.1038/s41598-017-12986-02045-2322https://doaj.org/article/e3ba237d1f564901811d13305024db732017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12986-0https://doaj.org/toc/2045-2322Abstract Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking for schizophrenia. We investigated associations between single nucleotide polymorphisms (SNPs) from the custom-made PsychArray and the expression levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 matched controls. We identified associations between 81 SNPs and 29 proteins, primarily involved in immune/inflammation responses. Significant SNPxDiagnosis interactions were identified for eight serum proteins including Factor-VII[rs555212], Alpha-1-Antitrypsin[rs11846959], Interferon-Gamma Induced Protein 10[rs4256246] and von-Willebrand-Factor[rs12829220] in the control group; Chromogranin-A[rs9658644], Cystatin-C[rs2424577] and Vitamin K-Dependent Protein S[rs6123] in the schizophrenia group; Interleukin-6 receptor[rs7553796] in both the control and schizophrenia groups. These results suggested that the effect of these SNPs on expression of the respective proteins varies with diagnosis. The combination of patient-specific genetic information with blood biomarker data opens a novel approach to investigate disease mechanisms in schizophrenia and other psychiatric disorders. Our findings not only suggest that blood protein expression is influenced by polymorphisms in the corresponding gene, but also that the effect of certain SNPs on expression of proteins can vary with diagnosis.Man K. ChanJason D. CooperStefanie Heilmann-HeimbachJosef FrankStephanie H. WittMarkus M. NöthenJohann SteinerMarcella RietschelSabine BahnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Man K. Chan Jason D. Cooper Stefanie Heilmann-Heimbach Josef Frank Stephanie H. Witt Markus M. Nöthen Johann Steiner Marcella Rietschel Sabine Bahn Associations between SNPs and immune-related circulating proteins in schizophrenia
description	Abstract Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking for schizophrenia. We investigated associations between single nucleotide polymorphisms (SNPs) from the custom-made PsychArray and the expression levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 matched controls. We identified associations between 81 SNPs and 29 proteins, primarily involved in immune/inflammation responses. Significant SNPxDiagnosis interactions were identified for eight serum proteins including Factor-VII[rs555212], Alpha-1-Antitrypsin[rs11846959], Interferon-Gamma Induced Protein 10[rs4256246] and von-Willebrand-Factor[rs12829220] in the control group; Chromogranin-A[rs9658644], Cystatin-C[rs2424577] and Vitamin K-Dependent Protein S[rs6123] in the schizophrenia group; Interleukin-6 receptor[rs7553796] in both the control and schizophrenia groups. These results suggested that the effect of these SNPs on expression of the respective proteins varies with diagnosis. The combination of patient-specific genetic information with blood biomarker data opens a novel approach to investigate disease mechanisms in schizophrenia and other psychiatric disorders. Our findings not only suggest that blood protein expression is influenced by polymorphisms in the corresponding gene, but also that the effect of certain SNPs on expression of proteins can vary with diagnosis.
format	article
author	Man K. Chan Jason D. Cooper Stefanie Heilmann-Heimbach Josef Frank Stephanie H. Witt Markus M. Nöthen Johann Steiner Marcella Rietschel Sabine Bahn
author_facet	Man K. Chan Jason D. Cooper Stefanie Heilmann-Heimbach Josef Frank Stephanie H. Witt Markus M. Nöthen Johann Steiner Marcella Rietschel Sabine Bahn
author_sort	Man K. Chan
title	Associations between SNPs and immune-related circulating proteins in schizophrenia
title_short	Associations between SNPs and immune-related circulating proteins in schizophrenia
title_full	Associations between SNPs and immune-related circulating proteins in schizophrenia
title_fullStr	Associations between SNPs and immune-related circulating proteins in schizophrenia
title_full_unstemmed	Associations between SNPs and immune-related circulating proteins in schizophrenia
title_sort	associations between snps and immune-related circulating proteins in schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3ba237d1f564901811d13305024db73
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Associations between SNPs and immune-related circulating proteins in schizophrenia

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