T cells specific for post-translational modifications escape intrathymic tolerance induction
Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic toler...
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Nature Portfolio
2018
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oai:doaj.org-article:e3bc31ec183743a0819cb2d858e9e59c2021-12-02T15:34:20ZT cells specific for post-translational modifications escape intrathymic tolerance induction10.1038/s41467-017-02763-y2041-1723https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02763-yhttps://doaj.org/toc/2041-1723Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.Bruno RaposoPatrick MerkyChristina LundqvistHisakata YamadaVilma UrbonaviciuteColin NiaudetJohan ViljanenJan KihlbergBruno KyewskiOlov EkwallRikard HolmdahlJohan BäcklundNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund T cells specific for post-translational modifications escape intrathymic tolerance induction |
description |
Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis. |
format |
article |
author |
Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund |
author_facet |
Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund |
author_sort |
Bruno Raposo |
title |
T cells specific for post-translational modifications escape intrathymic tolerance induction |
title_short |
T cells specific for post-translational modifications escape intrathymic tolerance induction |
title_full |
T cells specific for post-translational modifications escape intrathymic tolerance induction |
title_fullStr |
T cells specific for post-translational modifications escape intrathymic tolerance induction |
title_full_unstemmed |
T cells specific for post-translational modifications escape intrathymic tolerance induction |
title_sort |
t cells specific for post-translational modifications escape intrathymic tolerance induction |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c |
work_keys_str_mv |
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1718386871195664384 |