T cells specific for post-translational modifications escape intrathymic tolerance induction

Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic toler...

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Autores principales: Bruno Raposo, Patrick Merky, Christina Lundqvist, Hisakata Yamada, Vilma Urbonaviciute, Colin Niaudet, Johan Viljanen, Jan Kihlberg, Bruno Kyewski, Olov Ekwall, Rikard Holmdahl, Johan Bäcklund
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c
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spelling oai:doaj.org-article:e3bc31ec183743a0819cb2d858e9e59c2021-12-02T15:34:20ZT cells specific for post-translational modifications escape intrathymic tolerance induction10.1038/s41467-017-02763-y2041-1723https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02763-yhttps://doaj.org/toc/2041-1723Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.Bruno RaposoPatrick MerkyChristina LundqvistHisakata YamadaVilma UrbonaviciuteColin NiaudetJohan ViljanenJan KihlbergBruno KyewskiOlov EkwallRikard HolmdahlJohan BäcklundNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bruno Raposo
Patrick Merky
Christina Lundqvist
Hisakata Yamada
Vilma Urbonaviciute
Colin Niaudet
Johan Viljanen
Jan Kihlberg
Bruno Kyewski
Olov Ekwall
Rikard Holmdahl
Johan Bäcklund
T cells specific for post-translational modifications escape intrathymic tolerance induction
description Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.
format article
author Bruno Raposo
Patrick Merky
Christina Lundqvist
Hisakata Yamada
Vilma Urbonaviciute
Colin Niaudet
Johan Viljanen
Jan Kihlberg
Bruno Kyewski
Olov Ekwall
Rikard Holmdahl
Johan Bäcklund
author_facet Bruno Raposo
Patrick Merky
Christina Lundqvist
Hisakata Yamada
Vilma Urbonaviciute
Colin Niaudet
Johan Viljanen
Jan Kihlberg
Bruno Kyewski
Olov Ekwall
Rikard Holmdahl
Johan Bäcklund
author_sort Bruno Raposo
title T cells specific for post-translational modifications escape intrathymic tolerance induction
title_short T cells specific for post-translational modifications escape intrathymic tolerance induction
title_full T cells specific for post-translational modifications escape intrathymic tolerance induction
title_fullStr T cells specific for post-translational modifications escape intrathymic tolerance induction
title_full_unstemmed T cells specific for post-translational modifications escape intrathymic tolerance induction
title_sort t cells specific for post-translational modifications escape intrathymic tolerance induction
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c
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