T cells specific for post-translational modifications escape intrathymic tolerance induction

Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic toler...

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Autores principales:	Bruno Raposo, Patrick Merky, Christina Lundqvist, Hisakata Yamada, Vilma Urbonaviciute, Colin Niaudet, Johan Viljanen, Jan Kihlberg, Bruno Kyewski, Olov Ekwall, Rikard Holmdahl, Johan Bäcklund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c
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spelling	oai:doaj.org-article:e3bc31ec183743a0819cb2d858e9e59c2021-12-02T15:34:20ZT cells specific for post-translational modifications escape intrathymic tolerance induction10.1038/s41467-017-02763-y2041-1723https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02763-yhttps://doaj.org/toc/2041-1723Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.Bruno RaposoPatrick MerkyChristina LundqvistHisakata YamadaVilma UrbonaviciuteColin NiaudetJohan ViljanenJan KihlbergBruno KyewskiOlov EkwallRikard HolmdahlJohan BäcklundNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund T cells specific for post-translational modifications escape intrathymic tolerance induction
description	Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.
format	article
author	Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund
author_facet	Bruno Raposo Patrick Merky Christina Lundqvist Hisakata Yamada Vilma Urbonaviciute Colin Niaudet Johan Viljanen Jan Kihlberg Bruno Kyewski Olov Ekwall Rikard Holmdahl Johan Bäcklund
author_sort	Bruno Raposo
title	T cells specific for post-translational modifications escape intrathymic tolerance induction
title_short	T cells specific for post-translational modifications escape intrathymic tolerance induction
title_full	T cells specific for post-translational modifications escape intrathymic tolerance induction
title_fullStr	T cells specific for post-translational modifications escape intrathymic tolerance induction
title_full_unstemmed	T cells specific for post-translational modifications escape intrathymic tolerance induction
title_sort	t cells specific for post-translational modifications escape intrathymic tolerance induction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c
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T cells specific for post-translational modifications escape intrathymic tolerance induction

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