Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network

Abstract Intravascular microrobots have emerged as a promising tool for vascular diseases. They can be wirelessly and precisely manipulated with a high degree of freedom. Previous studies have evaluated their drilling performance and locomotion, and showed the feasibility of using microrobots for bi...

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Autores principales:	Sunkey Lee, Seungmin Lee, Sangwon Kim, Chang-Hwan Yoon, Hun-Jun Park, Jin-young Kim, Hongsoo Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3c1f08af8f9491fa4f3cea222f23542
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spelling	oai:doaj.org-article:e3c1f08af8f9491fa4f3cea222f235422021-12-02T15:08:48ZFabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network10.1038/s41598-018-22110-52045-2322https://doaj.org/article/e3c1f08af8f9491fa4f3cea222f235422018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22110-5https://doaj.org/toc/2045-2322Abstract Intravascular microrobots have emerged as a promising tool for vascular diseases. They can be wirelessly and precisely manipulated with a high degree of freedom. Previous studies have evaluated their drilling performance and locomotion, and showed the feasibility of using microrobots for biomedical applications in two-dimensional space. However, it is critical to validate micro-drillers in a three-dimensional (3D) environment because gravity plays an important role in a 3D environment and significantly affects the performance of the micro-drillers in vascular networks. In this work, we fabricated magnetic drilling actuators (MDAs) and characterized their locomotion and drilling performance in vascular network-mimicking fluidic channels. The MDAs were precisely manipulated in the fluidic channel network in both horizontal and vertical planes, selecting and moving through the desired path via the junctions of multiple channels. The MDAs also accurately navigated an artificial thrombosis in an artificial 3D vascular network and successfully drilled through it. The results obtained here confirmed the precise manipulation and drilling performance of the developed MDAs in 3D. We think that the MDAs presented in this paper have great potential as intravascular drillers for precise thrombus treatment.Sunkey LeeSeungmin LeeSangwon KimChang-Hwan YoonHun-Jun ParkJin-young KimHongsoo ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sunkey Lee Seungmin Lee Sangwon Kim Chang-Hwan Yoon Hun-Jun Park Jin-young Kim Hongsoo Choi Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
description	Abstract Intravascular microrobots have emerged as a promising tool for vascular diseases. They can be wirelessly and precisely manipulated with a high degree of freedom. Previous studies have evaluated their drilling performance and locomotion, and showed the feasibility of using microrobots for biomedical applications in two-dimensional space. However, it is critical to validate micro-drillers in a three-dimensional (3D) environment because gravity plays an important role in a 3D environment and significantly affects the performance of the micro-drillers in vascular networks. In this work, we fabricated magnetic drilling actuators (MDAs) and characterized their locomotion and drilling performance in vascular network-mimicking fluidic channels. The MDAs were precisely manipulated in the fluidic channel network in both horizontal and vertical planes, selecting and moving through the desired path via the junctions of multiple channels. The MDAs also accurately navigated an artificial thrombosis in an artificial 3D vascular network and successfully drilled through it. The results obtained here confirmed the precise manipulation and drilling performance of the developed MDAs in 3D. We think that the MDAs presented in this paper have great potential as intravascular drillers for precise thrombus treatment.
format	article
author	Sunkey Lee Seungmin Lee Sangwon Kim Chang-Hwan Yoon Hun-Jun Park Jin-young Kim Hongsoo Choi
author_facet	Sunkey Lee Seungmin Lee Sangwon Kim Chang-Hwan Yoon Hun-Jun Park Jin-young Kim Hongsoo Choi
author_sort	Sunkey Lee
title	Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
title_short	Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
title_full	Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
title_fullStr	Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
title_full_unstemmed	Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network
title_sort	fabrication and characterization of a magnetic drilling actuator for navigation in a three-dimensional phantom vascular network
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e3c1f08af8f9491fa4f3cea222f23542
work_keys_str_mv	AT sunkeylee fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT seungminlee fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT sangwonkim fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT changhwanyoon fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT hunjunpark fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT jinyoungkim fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork AT hongsoochoi fabricationandcharacterizationofamagneticdrillingactuatorfornavigationinathreedimensionalphantomvascularnetwork
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Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network

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