Infectious Keratitis: An Update on Role of Epigenetics

Epigenetic mechanisms modulate gene expression and function without altering the base sequence of DNA. These reversible, heritable, and environment-influenced mechanisms generate various cell types during development and orchestrate the cellular responses to external stimuli by regulating the expres...

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Autores principales:	Sudhir Verma, Aastha Singh, Akhil Varshney, R. Arun Chandru, Manisha Acharya, Jyoti Rajput, Virender Singh Sangwan, Amit K. Tiwari, Tuhin Bhowmick, Anil Tiwari
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	keratitis epigenetics methylation histone modifications infectious Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e3c5379e5b4b435f9033c62d36bc5723
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spelling	oai:doaj.org-article:e3c5379e5b4b435f9033c62d36bc57232021-12-01T18:01:56ZInfectious Keratitis: An Update on Role of Epigenetics1664-322410.3389/fimmu.2021.765890https://doaj.org/article/e3c5379e5b4b435f9033c62d36bc57232021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.765890/fullhttps://doaj.org/toc/1664-3224Epigenetic mechanisms modulate gene expression and function without altering the base sequence of DNA. These reversible, heritable, and environment-influenced mechanisms generate various cell types during development and orchestrate the cellular responses to external stimuli by regulating the expression of genome. Also, the epigenetic modifications influence common pathological and physiological responses including inflammation, ischemia, neoplasia, aging and neurodegeneration etc. In recent past, the field of epigenetics has gained momentum and become an increasingly important area of biomedical research As far as eye is concerned, epigenetic mechanisms may play an important role in many complex diseases such as corneal dystrophy, cataract, glaucoma, diabetic retinopathy, ocular neoplasia, uveitis, and age-related macular degeneration. Focusing on the epigenetic mechanisms in ocular diseases may provide new understanding and insights into the pathogenesis of complex eye diseases and thus can aid in the development of novel treatments for these diseases. In the present review, we summarize the clinical perspective of infectious keratitis, role of epigenetics in infectious keratitis, therapeutic potential of epigenetic modifiers and the future perspective.Sudhir VermaAastha SinghAkhil VarshneyR. Arun ChandruManisha AcharyaJyoti RajputVirender Singh SangwanAmit K. TiwariTuhin BhowmickAnil TiwariFrontiers Media S.A.articlekeratitisepigeneticsmethylationhistone modificationsinfectiousImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratitis epigenetics methylation histone modifications infectious Immunologic diseases. Allergy RC581-607
spellingShingle	keratitis epigenetics methylation histone modifications infectious Immunologic diseases. Allergy RC581-607 Sudhir Verma Aastha Singh Akhil Varshney R. Arun Chandru Manisha Acharya Jyoti Rajput Virender Singh Sangwan Amit K. Tiwari Tuhin Bhowmick Anil Tiwari Infectious Keratitis: An Update on Role of Epigenetics
description	Epigenetic mechanisms modulate gene expression and function without altering the base sequence of DNA. These reversible, heritable, and environment-influenced mechanisms generate various cell types during development and orchestrate the cellular responses to external stimuli by regulating the expression of genome. Also, the epigenetic modifications influence common pathological and physiological responses including inflammation, ischemia, neoplasia, aging and neurodegeneration etc. In recent past, the field of epigenetics has gained momentum and become an increasingly important area of biomedical research As far as eye is concerned, epigenetic mechanisms may play an important role in many complex diseases such as corneal dystrophy, cataract, glaucoma, diabetic retinopathy, ocular neoplasia, uveitis, and age-related macular degeneration. Focusing on the epigenetic mechanisms in ocular diseases may provide new understanding and insights into the pathogenesis of complex eye diseases and thus can aid in the development of novel treatments for these diseases. In the present review, we summarize the clinical perspective of infectious keratitis, role of epigenetics in infectious keratitis, therapeutic potential of epigenetic modifiers and the future perspective.
format	article
author	Sudhir Verma Aastha Singh Akhil Varshney R. Arun Chandru Manisha Acharya Jyoti Rajput Virender Singh Sangwan Amit K. Tiwari Tuhin Bhowmick Anil Tiwari
author_facet	Sudhir Verma Aastha Singh Akhil Varshney R. Arun Chandru Manisha Acharya Jyoti Rajput Virender Singh Sangwan Amit K. Tiwari Tuhin Bhowmick Anil Tiwari
author_sort	Sudhir Verma
title	Infectious Keratitis: An Update on Role of Epigenetics
title_short	Infectious Keratitis: An Update on Role of Epigenetics
title_full	Infectious Keratitis: An Update on Role of Epigenetics
title_fullStr	Infectious Keratitis: An Update on Role of Epigenetics
title_full_unstemmed	Infectious Keratitis: An Update on Role of Epigenetics
title_sort	infectious keratitis: an update on role of epigenetics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e3c5379e5b4b435f9033c62d36bc5723
work_keys_str_mv	AT sudhirverma infectiouskeratitisanupdateonroleofepigenetics AT aasthasingh infectiouskeratitisanupdateonroleofepigenetics AT akhilvarshney infectiouskeratitisanupdateonroleofepigenetics AT rarunchandru infectiouskeratitisanupdateonroleofepigenetics AT manishaacharya infectiouskeratitisanupdateonroleofepigenetics AT jyotirajput infectiouskeratitisanupdateonroleofepigenetics AT virendersinghsangwan infectiouskeratitisanupdateonroleofepigenetics AT amitktiwari infectiouskeratitisanupdateonroleofepigenetics AT tuhinbhowmick infectiouskeratitisanupdateonroleofepigenetics AT aniltiwari infectiouskeratitisanupdateonroleofepigenetics
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Infectious Keratitis: An Update on Role of Epigenetics

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