Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus with Increased Virulence in Mice

Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus with Increased Virulence in Mice

ABSTRACT In 2009, a novel H1N1 influenza A virus (2009 pH1N1) emerged and caused a pandemic. A human monoclonal antibody (hMAb; EM4C04), highly specific for the 2009 pH1N1 virus hemagglutinin (HA), was isolated from a severely ill 2009 pH1N1 virus-infected patient. We postulated that under immune pr...

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Autores principales: Christopher D. O’Donnell, Leatrice Vogel, Amber Wright, Suman R. Das, Jens Wrammert, Gui-Mei Li, Megan McCausland, Nai-Ying Zheng, Jonathan W. Yewdell, Rafi Ahmed, Patrick C. Wilson, Kanta Subbarao
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2012
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e3c80ee632d5479eb1e19c0af662f15d
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