N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA

N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA

N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification, decreases viral ds RNA content, and thereby dampens...

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Autores principales: Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, Yun-Gui Yang, Pengyuan Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/e3ca47ef6654412d86d5ab34d1d96bcf
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spelling oai:doaj.org-article:e3ca47ef6654412d86d5ab34d1d96bcf2021-12-02T13:34:29ZN 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA10.1038/s41467-021-21904-y2041-1723https://doaj.org/article/e3ca47ef6654412d86d5ab34d1d96bcf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21904-yhttps://doaj.org/toc/2041-1723N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.Weinan QiuQingyang ZhangRui ZhangYangxu LuXin WangHuabin TianYing YangZijuan GuYanan GaoXin YangGuanshen CuiBaofa SunYanan PengHongyu DengHua PengAngang YangYun-Gui YangPengyuan YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weinan Qiu
Qingyang Zhang
Rui Zhang
Yangxu Lu
Xin Wang
Huabin Tian
Ying Yang
Zijuan Gu
Yanan Gao
Xin Yang
Guanshen Cui
Baofa Sun
Yanan Peng
Hongyu Deng
Hua Peng
Angang Yang
Yun-Gui Yang
Pengyuan Yang
N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
description N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.
format article
author Weinan Qiu
Qingyang Zhang
Rui Zhang
Yangxu Lu
Xin Wang
Huabin Tian
Ying Yang
Zijuan Gu
Yanan Gao
Xin Yang
Guanshen Cui
Baofa Sun
Yanan Peng
Hongyu Deng
Hua Peng
Angang Yang
Yun-Gui Yang
Pengyuan Yang
author_facet Weinan Qiu
Qingyang Zhang
Rui Zhang
Yangxu Lu
Xin Wang
Huabin Tian
Ying Yang
Zijuan Gu
Yanan Gao
Xin Yang
Guanshen Cui
Baofa Sun
Yanan Peng
Hongyu Deng
Hua Peng
Angang Yang
Yun-Gui Yang
Pengyuan Yang
author_sort Weinan Qiu
title N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
title_short N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
title_full N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
title_fullStr N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
title_full_unstemmed N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
title_sort n 6-methyladenosine rna modification suppresses antiviral innate sensing pathways via reshaping double-stranded rna
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e3ca47ef6654412d86d5ab34d1d96bcf
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