Deacetylation of Transcription Factors in Carcinogenesis

Reversible Nε-lysine acetylation/deacetylation is one of the most common post-translational modifications (PTM) of histones and non-histone proteins that is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). This epigenetic process is highly involved in carcinogenesis,...

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Autores principales:	Marta Halasa, Kamila Adamczuk, Grzegorz Adamczuk, Syeda Afshan, Andrzej Stepulak, Marek Cybulski, Anna Wawruszak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HDAC histone deacetylase inhibitors (HDIs) transcription factors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e3cd48bdd4334780830464e4ba66298b
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spelling	oai:doaj.org-article:e3cd48bdd4334780830464e4ba66298b2021-11-11T17:15:10ZDeacetylation of Transcription Factors in Carcinogenesis10.3390/ijms2221118101422-00671661-6596https://doaj.org/article/e3cd48bdd4334780830464e4ba66298b2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11810https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Reversible Nε-lysine acetylation/deacetylation is one of the most common post-translational modifications (PTM) of histones and non-histone proteins that is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). This epigenetic process is highly involved in carcinogenesis, affecting histone and non-histone proteins’ properties and their biological functions. Some of the transcription factors, including tumor suppressors and oncoproteins, undergo this modification altering different cell signaling pathways. HDACs deacetylate their targets, which leads to either the upregulation or downregulation of proteins involved in the regulation of cell cycle and apoptosis, ultimately influencing tumor growth, invasion, and drug resistance. Therefore, epigenetic modifications are of great clinical importance and may constitute a new therapeutic target in cancer treatment. This review is aimed to present the significance of HDACs in carcinogenesis through their influence on functions of transcription factors, and therefore regulation of different signaling pathways, cancer progression, and metastasis.Marta HalasaKamila AdamczukGrzegorz AdamczukSyeda AfshanAndrzej StepulakMarek CybulskiAnna WawruszakMDPI AGarticleHDAChistone deacetylase inhibitors (HDIs)transcription factorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11810, p 11810 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HDAC histone deacetylase inhibitors (HDIs) transcription factors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	HDAC histone deacetylase inhibitors (HDIs) transcription factors Biology (General) QH301-705.5 Chemistry QD1-999 Marta Halasa Kamila Adamczuk Grzegorz Adamczuk Syeda Afshan Andrzej Stepulak Marek Cybulski Anna Wawruszak Deacetylation of Transcription Factors in Carcinogenesis
description	Reversible Nε-lysine acetylation/deacetylation is one of the most common post-translational modifications (PTM) of histones and non-histone proteins that is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). This epigenetic process is highly involved in carcinogenesis, affecting histone and non-histone proteins’ properties and their biological functions. Some of the transcription factors, including tumor suppressors and oncoproteins, undergo this modification altering different cell signaling pathways. HDACs deacetylate their targets, which leads to either the upregulation or downregulation of proteins involved in the regulation of cell cycle and apoptosis, ultimately influencing tumor growth, invasion, and drug resistance. Therefore, epigenetic modifications are of great clinical importance and may constitute a new therapeutic target in cancer treatment. This review is aimed to present the significance of HDACs in carcinogenesis through their influence on functions of transcription factors, and therefore regulation of different signaling pathways, cancer progression, and metastasis.
format	article
author	Marta Halasa Kamila Adamczuk Grzegorz Adamczuk Syeda Afshan Andrzej Stepulak Marek Cybulski Anna Wawruszak
author_facet	Marta Halasa Kamila Adamczuk Grzegorz Adamczuk Syeda Afshan Andrzej Stepulak Marek Cybulski Anna Wawruszak
author_sort	Marta Halasa
title	Deacetylation of Transcription Factors in Carcinogenesis
title_short	Deacetylation of Transcription Factors in Carcinogenesis
title_full	Deacetylation of Transcription Factors in Carcinogenesis
title_fullStr	Deacetylation of Transcription Factors in Carcinogenesis
title_full_unstemmed	Deacetylation of Transcription Factors in Carcinogenesis
title_sort	deacetylation of transcription factors in carcinogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e3cd48bdd4334780830464e4ba66298b
work_keys_str_mv	AT martahalasa deacetylationoftranscriptionfactorsincarcinogenesis AT kamilaadamczuk deacetylationoftranscriptionfactorsincarcinogenesis AT grzegorzadamczuk deacetylationoftranscriptionfactorsincarcinogenesis AT syedaafshan deacetylationoftranscriptionfactorsincarcinogenesis AT andrzejstepulak deacetylationoftranscriptionfactorsincarcinogenesis AT marekcybulski deacetylationoftranscriptionfactorsincarcinogenesis AT annawawruszak deacetylationoftranscriptionfactorsincarcinogenesis
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Deacetylation of Transcription Factors in Carcinogenesis

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