SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy

Abstract Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. Subjects filled a questionnaire to self-report...

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Autores principales:	Maria Teresa Sandri, Elena Azzolini, Valter Torri, Sara Carloni, Chiara Pozzi, Michela Salvatici, Michele Tedeschi, Massimo Castoldi, Alberto Mantovani, Maria Rescigno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3d28c883efd4bb1bb466600b77563a9
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spelling	oai:doaj.org-article:e3d28c883efd4bb1bb466600b77563a92021-12-02T17:34:31ZSARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy10.1038/s41598-021-91773-42045-2322https://doaj.org/article/e3d28c883efd4bb1bb466600b77563a92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91773-4https://doaj.org/toc/2045-2322Abstract Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. Subjects filled a questionnaire to self-report on COVID-19 symptoms, comorbidities, smoking, regular or remote working, and the exposure to COVID-infected individuals. We show that the number of individuals exposed to the virus depended on the geographical location of the facility, ranging between 3 and 43%, consistent with the spatial variation of COVID-19 incidence in Lombardy, and correlated with family interactions. We observed a higher prevalence of females than males positive for IgG, however the level of antibodies was similar, suggesting a comparable magnitude of the anti-spike antibody response. IgG positivity among smokers was lower (7.4% vs 13.5%) although without difference in IgG plasma levels. We observed 11.9% of IgG positive asymptomatic individuals and another 23.1% with one or two symptoms. Interestingly, among the IgG positive population, 81.2% of subjects with anosmia/dysgeusia and fever were SARS-CoV-2 infected, indicating that these symptoms are strongly associated to COVID-19. In conclusion, the frequency of IgG positivity and SARS-CoV-2 infection is dependent on the geographical exposure to the virus and primarily to family rather than hospital exposure.Maria Teresa SandriElena AzzoliniValter TorriSara CarloniChiara PozziMichela SalvaticiMichele TedeschiMassimo CastoldiAlberto MantovaniMaria RescignoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Teresa Sandri Elena Azzolini Valter Torri Sara Carloni Chiara Pozzi Michela Salvatici Michele Tedeschi Massimo Castoldi Alberto Mantovani Maria Rescigno SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
description	Abstract Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. Subjects filled a questionnaire to self-report on COVID-19 symptoms, comorbidities, smoking, regular or remote working, and the exposure to COVID-infected individuals. We show that the number of individuals exposed to the virus depended on the geographical location of the facility, ranging between 3 and 43%, consistent with the spatial variation of COVID-19 incidence in Lombardy, and correlated with family interactions. We observed a higher prevalence of females than males positive for IgG, however the level of antibodies was similar, suggesting a comparable magnitude of the anti-spike antibody response. IgG positivity among smokers was lower (7.4% vs 13.5%) although without difference in IgG plasma levels. We observed 11.9% of IgG positive asymptomatic individuals and another 23.1% with one or two symptoms. Interestingly, among the IgG positive population, 81.2% of subjects with anosmia/dysgeusia and fever were SARS-CoV-2 infected, indicating that these symptoms are strongly associated to COVID-19. In conclusion, the frequency of IgG positivity and SARS-CoV-2 infection is dependent on the geographical exposure to the virus and primarily to family rather than hospital exposure.
format	article
author	Maria Teresa Sandri Elena Azzolini Valter Torri Sara Carloni Chiara Pozzi Michela Salvatici Michele Tedeschi Massimo Castoldi Alberto Mantovani Maria Rescigno
author_facet	Maria Teresa Sandri Elena Azzolini Valter Torri Sara Carloni Chiara Pozzi Michela Salvatici Michele Tedeschi Massimo Castoldi Alberto Mantovani Maria Rescigno
author_sort	Maria Teresa Sandri
title	SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
title_short	SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
title_full	SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
title_fullStr	SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
title_full_unstemmed	SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
title_sort	sars-cov-2 serology in 4000 health care and administrative staff across seven sites in lombardy, italy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3d28c883efd4bb1bb466600b77563a9
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SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy

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