Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure.

Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure.

Protein malnutrition (PM) results in pathological changes that are associated with peripheral leukopenia, bone marrow (BM) hypoplasia and alterations in the BM microenvironment leading to hematopoietic failure; however, the mechanisms involved are poorly understood. In this context, the BM mesenchym...

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Bibliographic Details
Main Authors: Mayara Caldas Ramos Cunha, Fabiana da Silva Lima, Marco Aurélio Ramirez Vinolo, Araceli Hastreiter, Rui Curi, Primavera Borelli, Ricardo Ambrósio Fock
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/e3d55d0dbc9246f49a98b0918b40400a
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