Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

Abstract This study aimed to evaluate whether the relationship between obesity and erosive reflux disease (ERD) is mediated by cardiometabolic risk factors. This cohort study included subjects who underwent repeated endoscopy. To assess whether the association between body mass index (BMI) and ERD d...

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Autores principales:	Hyuk Lee, Yaeji Lim, Sangah Chi, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae J. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3de221f3f444646a4a1caaafc0a169a
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spelling	oai:doaj.org-article:e3de221f3f444646a4a1caaafc0a169a2021-12-02T11:40:30ZRelationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors10.1038/s41598-017-06845-12045-2322https://doaj.org/article/e3de221f3f444646a4a1caaafc0a169a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06845-1https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate whether the relationship between obesity and erosive reflux disease (ERD) is mediated by cardiometabolic risk factors. This cohort study included subjects who underwent repeated endoscopy. To assess whether the association between body mass index (BMI) and ERD development was mediated by cardiometabolic parameters, multivariate Cox proportional hazard models were fitted for mediation analysis. Of 15,154 subjects with negative index endoscopy findings during health check-up, 11,686 subjects who underwent repeated endoscopy were included. During follow-up, 1,367 incident ERD events (11.7%) were observed. Without mediation effect, the multivariate adjusted hazard ratio of BMI was 1.21 (95% CI, 1.03–1.42) in overweight and 1.39 (95% CI, 1.19–1.62) in obese individuals compared to normal weight individuals. When the metabolic syndrome was included as a mediator, the hazard ratio became 1.19 (95% CI, 1.00–1.40) in overweight and 1.29 (95% CI, 1.10–1.52) in obese individuals. Both systolic blood pressure and triglyceride level were found to fully mediate the effect of BMI on ERD. Fasting glucose level was a partial mediator. The estimated percentage of total effect mediated by cardiometabolic risk factors was 35.4%. Cardiometabolic parameters partially or fully mediate the association between overweight and obesity and incident ERD.Hyuk LeeYaeji LimSangah ChiYang Won MinByung-Hoon MinJun Haeng LeePoong-Lyul RheeJae J. KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyuk Lee Yaeji Lim Sangah Chi Yang Won Min Byung-Hoon Min Jun Haeng Lee Poong-Lyul Rhee Jae J. Kim Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
description	Abstract This study aimed to evaluate whether the relationship between obesity and erosive reflux disease (ERD) is mediated by cardiometabolic risk factors. This cohort study included subjects who underwent repeated endoscopy. To assess whether the association between body mass index (BMI) and ERD development was mediated by cardiometabolic parameters, multivariate Cox proportional hazard models were fitted for mediation analysis. Of 15,154 subjects with negative index endoscopy findings during health check-up, 11,686 subjects who underwent repeated endoscopy were included. During follow-up, 1,367 incident ERD events (11.7%) were observed. Without mediation effect, the multivariate adjusted hazard ratio of BMI was 1.21 (95% CI, 1.03–1.42) in overweight and 1.39 (95% CI, 1.19–1.62) in obese individuals compared to normal weight individuals. When the metabolic syndrome was included as a mediator, the hazard ratio became 1.19 (95% CI, 1.00–1.40) in overweight and 1.29 (95% CI, 1.10–1.52) in obese individuals. Both systolic blood pressure and triglyceride level were found to fully mediate the effect of BMI on ERD. Fasting glucose level was a partial mediator. The estimated percentage of total effect mediated by cardiometabolic risk factors was 35.4%. Cardiometabolic parameters partially or fully mediate the association between overweight and obesity and incident ERD.
format	article
author	Hyuk Lee Yaeji Lim Sangah Chi Yang Won Min Byung-Hoon Min Jun Haeng Lee Poong-Lyul Rhee Jae J. Kim
author_facet	Hyuk Lee Yaeji Lim Sangah Chi Yang Won Min Byung-Hoon Min Jun Haeng Lee Poong-Lyul Rhee Jae J. Kim
author_sort	Hyuk Lee
title	Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
title_short	Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
title_full	Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
title_fullStr	Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
title_full_unstemmed	Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors
title_sort	relationship between obesity and development of erosive reflux disease: a mediation analysis of the role of cardiometabolic risk factors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3de221f3f444646a4a1caaafc0a169a
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Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

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