Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies

Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospectively isolate restorative cell subpopulations.

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Autores principales:	Robert C. Rennert, Michael Januszyk, Michael Sorkin, Melanie Rodrigues, Zeshaan N. Maan, Dominik Duscher, Alexander J. Whittam, Revanth Kosaraju, Michael T. Chung, Kevin Paik, Alexander Y. Li, Michael Findlay, Jason P. Glotzbach, Atul J. Butte, Geoffrey C. Gurtner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3e19ba12cdd407ca10537b23a1ba94c
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spelling	oai:doaj.org-article:e3e19ba12cdd407ca10537b23a1ba94c2021-12-02T16:49:26ZMicrofluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies10.1038/ncomms119452041-1723https://doaj.org/article/e3e19ba12cdd407ca10537b23a1ba94c2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11945https://doaj.org/toc/2041-1723Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospectively isolate restorative cell subpopulations.Robert C. RennertMichael JanuszykMichael SorkinMelanie RodriguesZeshaan N. MaanDominik DuscherAlexander J. WhittamRevanth KosarajuMichael T. ChungKevin PaikAlexander Y. LiMichael FindlayJason P. GlotzbachAtul J. ButteGeoffrey C. GurtnerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert C. Rennert Michael Januszyk Michael Sorkin Melanie Rodrigues Zeshaan N. Maan Dominik Duscher Alexander J. Whittam Revanth Kosaraju Michael T. Chung Kevin Paik Alexander Y. Li Michael Findlay Jason P. Glotzbach Atul J. Butte Geoffrey C. Gurtner Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
description	Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospectively isolate restorative cell subpopulations.
format	article
author	Robert C. Rennert Michael Januszyk Michael Sorkin Melanie Rodrigues Zeshaan N. Maan Dominik Duscher Alexander J. Whittam Revanth Kosaraju Michael T. Chung Kevin Paik Alexander Y. Li Michael Findlay Jason P. Glotzbach Atul J. Butte Geoffrey C. Gurtner
author_facet	Robert C. Rennert Michael Januszyk Michael Sorkin Melanie Rodrigues Zeshaan N. Maan Dominik Duscher Alexander J. Whittam Revanth Kosaraju Michael T. Chung Kevin Paik Alexander Y. Li Michael Findlay Jason P. Glotzbach Atul J. Butte Geoffrey C. Gurtner
author_sort	Robert C. Rennert
title	Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
title_short	Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
title_full	Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
title_fullStr	Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
title_full_unstemmed	Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
title_sort	microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e3e19ba12cdd407ca10537b23a1ba94c
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Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies

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