Understanding protection from SARS-CoV-2 using metabolomics

Abstract The COVID-19 pandemic is still raging in most countries. Although the recent mass vaccination campaign has opened a new chapter in the battle against SARS-CoV-2, the world is still far from herd immunity. There is an urgent need to identify healthy people at high risk of contracting COVID-1...

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Autores principales:	Elettra Barberis, Elia Amede, Matteo Tavecchia, Emilio Marengo, Micol G. Cittone, Eleonora Rizzi, Anita R. Pedrinelli, Stelvio Tonello, Rosalba Minisini, Mario Pirisi, Marcello Manfredi, Pier Paolo Sainaghi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3e34f887d424f4aaeca3aa2678e9997
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spelling	oai:doaj.org-article:e3e34f887d424f4aaeca3aa2678e99972021-12-02T15:39:59ZUnderstanding protection from SARS-CoV-2 using metabolomics10.1038/s41598-021-93260-22045-2322https://doaj.org/article/e3e34f887d424f4aaeca3aa2678e99972021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93260-2https://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic is still raging in most countries. Although the recent mass vaccination campaign has opened a new chapter in the battle against SARS-CoV-2, the world is still far from herd immunity. There is an urgent need to identify healthy people at high risk of contracting COVID-19, as well as supplements and nutraceuticals that can reduce the risk of infection or mitigate symptoms. In the present study, a metabolic phenotype that could protect individuals from SARS-CoV-2 infection or predispose them to developing COVID-19 was investigated. Untargeted metabolomics was performed on serum samples collected from 51 healthcare workers who were in good health at the beginning of the COVID-19 outbreak in Italy, and who were later exposed to the same risk of developing COVID-19. Half of them developed COVID-19 within three weeks of the blood collection. Our results demonstrate the presence of a specific signature associated with protection from SARS-CoV-2. Circulating monolaurin, which has well-known antiviral and antibacterial properties, was higher in protected subjects, suggesting a potential defensive role against SARS-CoV-2 infection; thus, dietary supplements could boost the immune system against this infection. In addition, our data demonstrate that people with higher levels of cholesterol are at higher risk of developing COVID-19. The present study demonstrates that metabolomics can be of great help for developing personalized medicine and for supporting public healthcare strategies. Studies with larger cohorts of subjects are necessary to confirm our findings.Elettra BarberisElia AmedeMatteo TavecchiaEmilio MarengoMicol G. CittoneEleonora RizziAnita R. PedrinelliStelvio TonelloRosalba MinisiniMario PirisiMarcello ManfrediPier Paolo SainaghiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elettra Barberis Elia Amede Matteo Tavecchia Emilio Marengo Micol G. Cittone Eleonora Rizzi Anita R. Pedrinelli Stelvio Tonello Rosalba Minisini Mario Pirisi Marcello Manfredi Pier Paolo Sainaghi Understanding protection from SARS-CoV-2 using metabolomics
description	Abstract The COVID-19 pandemic is still raging in most countries. Although the recent mass vaccination campaign has opened a new chapter in the battle against SARS-CoV-2, the world is still far from herd immunity. There is an urgent need to identify healthy people at high risk of contracting COVID-19, as well as supplements and nutraceuticals that can reduce the risk of infection or mitigate symptoms. In the present study, a metabolic phenotype that could protect individuals from SARS-CoV-2 infection or predispose them to developing COVID-19 was investigated. Untargeted metabolomics was performed on serum samples collected from 51 healthcare workers who were in good health at the beginning of the COVID-19 outbreak in Italy, and who were later exposed to the same risk of developing COVID-19. Half of them developed COVID-19 within three weeks of the blood collection. Our results demonstrate the presence of a specific signature associated with protection from SARS-CoV-2. Circulating monolaurin, which has well-known antiviral and antibacterial properties, was higher in protected subjects, suggesting a potential defensive role against SARS-CoV-2 infection; thus, dietary supplements could boost the immune system against this infection. In addition, our data demonstrate that people with higher levels of cholesterol are at higher risk of developing COVID-19. The present study demonstrates that metabolomics can be of great help for developing personalized medicine and for supporting public healthcare strategies. Studies with larger cohorts of subjects are necessary to confirm our findings.
format	article
author	Elettra Barberis Elia Amede Matteo Tavecchia Emilio Marengo Micol G. Cittone Eleonora Rizzi Anita R. Pedrinelli Stelvio Tonello Rosalba Minisini Mario Pirisi Marcello Manfredi Pier Paolo Sainaghi
author_facet	Elettra Barberis Elia Amede Matteo Tavecchia Emilio Marengo Micol G. Cittone Eleonora Rizzi Anita R. Pedrinelli Stelvio Tonello Rosalba Minisini Mario Pirisi Marcello Manfredi Pier Paolo Sainaghi
author_sort	Elettra Barberis
title	Understanding protection from SARS-CoV-2 using metabolomics
title_short	Understanding protection from SARS-CoV-2 using metabolomics
title_full	Understanding protection from SARS-CoV-2 using metabolomics
title_fullStr	Understanding protection from SARS-CoV-2 using metabolomics
title_full_unstemmed	Understanding protection from SARS-CoV-2 using metabolomics
title_sort	understanding protection from sars-cov-2 using metabolomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3e34f887d424f4aaeca3aa2678e9997
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_version_	1718385905688903680

Understanding protection from SARS-CoV-2 using metabolomics

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