An Emerging Role for Epigenetics in Cerebral Palsy

Cerebral palsy is a set of common, severe, motor disabilities categorized by a static, nondegenerative encephalopathy arising in the developing brain and associated with deficits in movement, posture, and activity. Spastic CP, which is the most common type, involves high muscle tone and is associate...

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Autores principales:	Brigette Romero, Karyn G. Robinson, Mona Batish, Robert E. Akins
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epigenomics DNA methylation histone modification noncoding RNA spasticity neonatal encephalopathy Medicine R
Acceso en línea:	https://doaj.org/article/e3e420545f174d9a85707927d1c656d8
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spelling	oai:doaj.org-article:e3e420545f174d9a85707927d1c656d82021-11-25T18:07:52ZAn Emerging Role for Epigenetics in Cerebral Palsy10.3390/jpm111111872075-4426https://doaj.org/article/e3e420545f174d9a85707927d1c656d82021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1187https://doaj.org/toc/2075-4426Cerebral palsy is a set of common, severe, motor disabilities categorized by a static, nondegenerative encephalopathy arising in the developing brain and associated with deficits in movement, posture, and activity. Spastic CP, which is the most common type, involves high muscle tone and is associated with altered muscle function including poor muscle growth and contracture, increased extracellular matrix deposition, microanatomic disruption, musculoskeletal deformities, weakness, and difficult movement control. These muscle-related manifestations of CP are major causes of progressive debilitation and frequently require intensive surgical and therapeutic intervention to control. Current clinical approaches involve sophisticated consideration of biomechanics, radiologic assessments, and movement analyses, but outcomes remain difficult to predict. There is a need for more precise and personalized approaches involving omics technologies, data science, and advanced analytics. An improved understanding of muscle involvement in spastic CP is needed. Unfortunately, the fundamental mechanisms and molecular pathways contributing to altered muscle function in spastic CP are only partially understood. In this review, we outline evidence supporting the emerging hypothesis that epigenetic phenomena play significant roles in musculoskeletal manifestations of CP.Brigette RomeroKaryn G. RobinsonMona BatishRobert E. AkinsMDPI AGarticleepigenomicsDNA methylationhistone modificationnoncoding RNAspasticityneonatal encephalopathyMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1187, p 1187 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenomics DNA methylation histone modification noncoding RNA spasticity neonatal encephalopathy Medicine R
spellingShingle	epigenomics DNA methylation histone modification noncoding RNA spasticity neonatal encephalopathy Medicine R Brigette Romero Karyn G. Robinson Mona Batish Robert E. Akins An Emerging Role for Epigenetics in Cerebral Palsy
description	Cerebral palsy is a set of common, severe, motor disabilities categorized by a static, nondegenerative encephalopathy arising in the developing brain and associated with deficits in movement, posture, and activity. Spastic CP, which is the most common type, involves high muscle tone and is associated with altered muscle function including poor muscle growth and contracture, increased extracellular matrix deposition, microanatomic disruption, musculoskeletal deformities, weakness, and difficult movement control. These muscle-related manifestations of CP are major causes of progressive debilitation and frequently require intensive surgical and therapeutic intervention to control. Current clinical approaches involve sophisticated consideration of biomechanics, radiologic assessments, and movement analyses, but outcomes remain difficult to predict. There is a need for more precise and personalized approaches involving omics technologies, data science, and advanced analytics. An improved understanding of muscle involvement in spastic CP is needed. Unfortunately, the fundamental mechanisms and molecular pathways contributing to altered muscle function in spastic CP are only partially understood. In this review, we outline evidence supporting the emerging hypothesis that epigenetic phenomena play significant roles in musculoskeletal manifestations of CP.
format	article
author	Brigette Romero Karyn G. Robinson Mona Batish Robert E. Akins
author_facet	Brigette Romero Karyn G. Robinson Mona Batish Robert E. Akins
author_sort	Brigette Romero
title	An Emerging Role for Epigenetics in Cerebral Palsy
title_short	An Emerging Role for Epigenetics in Cerebral Palsy
title_full	An Emerging Role for Epigenetics in Cerebral Palsy
title_fullStr	An Emerging Role for Epigenetics in Cerebral Palsy
title_full_unstemmed	An Emerging Role for Epigenetics in Cerebral Palsy
title_sort	emerging role for epigenetics in cerebral palsy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e3e420545f174d9a85707927d1c656d8
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An Emerging Role for Epigenetics in Cerebral Palsy

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