MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia
Abdullah A Mobarki,1 Gasim Dobie,1 Muhammad Saboor,1,2 Aymen M Madkhali,1 Mohammad S Akhter,1 Ali Hakamy,3 Adel Humran,4 Yousof Hamali,5 Denise E Jackson,6 Hassan A Hamali1 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia; 2Medi...
Guardado en:
Autores principales: | , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Dove Medical Press
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e3e52dd0ae5847ffa1c557e74bbaea6b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:e3e52dd0ae5847ffa1c557e74bbaea6b |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:e3e52dd0ae5847ffa1c557e74bbaea6b2021-11-23T18:43:01ZMPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia1178-6973https://doaj.org/article/e3e52dd0ae5847ffa1c557e74bbaea6b2021-11-01T00:00:00Zhttps://www.dovepress.com/mpr-and-nlr-as-prognostic-markers-in-icu-admitted-patients-with-covid--peer-reviewed-fulltext-article-IDRhttps://doaj.org/toc/1178-6973Abdullah A Mobarki,1 Gasim Dobie,1 Muhammad Saboor,1,2 Aymen M Madkhali,1 Mohammad S Akhter,1 Ali Hakamy,3 Adel Humran,4 Yousof Hamali,5 Denise E Jackson,6 Hassan A Hamali1 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia; 2Medical Research Center, Jazan University, Gizan, Saudi Arabia; 3Department of Respiratory Therapy, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia; 4Respiratory Care Department, King Fahad Central Hospital, Gizan, Saudi Arabia; 5Radiodiagnostics and Medical Imaging Department, Prince Sultan Medical City, Riyadh, Saudi Arabia; 6Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC, AustraliaCorrespondence: Hassan A HamaliDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, P.O. Box 1906, Gizan, 45142, Saudi ArabiaTel +966581155585Email hhamali@jazanu.edu.saObjective: The aims of the current study were to evaluate the importance of MPR and NLR as prognostic markers in ICU-admitted COVID-19 patients and to investigate the impact of COVID-19 on hematological and coagulation parameters in patients from Jazan region of Saudi Arabia.Methods: This retrospective study was conducted between October 2020 and January 2021 at King Fahad Central Hospital, Jazan region. Medical files, which included the results of complete blood count (CBC), calculated mean platelet volume to platelet count ratio (MPR) and neutrophils-to-lymphocytes ratio (NLR) parameters, coagulation profile and D-dimer test, of 96 (64 male and 32 female) COVID-19-infected patients admitted to the intensive care unit were reviewed. Associations between the test results and COVID-19 infection outcomes (discharged [DC] or passed away [PA]) were measured.Results: The results of the current study demonstrate overall significant differences in CBC parameters between PA group as compared to DC group (P < 0.05). The PA group had a significantly elevated MPR (10.15± 12.16 vs 4.04± 1.5; P < 0.01) and NLR (18.29± 19.82 vs 7.35± 9.68; P < 0.01) as compared to the DC group, suggesting an association between these parameters and mortality. Odds ratios analysis also showed that adjustment for demographic variables and comorbidities did not weaken the observed association.Conclusion: Elevated MPR and NLR are associated with poor prognosis in COVID-19 patients and could be useful as therapy management indicators.Keywords: COVID-19, NLR, MPR, ICU, CBC, mortalityMobarki AADobie GSaboor MMadkhali AMAkhter MSHakamy AHumran AHamali YJackson DEHamali HADove Medical Pressarticlecovid-19nlrmpricucbcmortalityInfectious and parasitic diseasesRC109-216ENInfection and Drug Resistance, Vol Volume 14, Pp 4859-4864 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
covid-19 nlr mpr icu cbc mortality Infectious and parasitic diseases RC109-216 |
spellingShingle |
covid-19 nlr mpr icu cbc mortality Infectious and parasitic diseases RC109-216 Mobarki AA Dobie G Saboor M Madkhali AM Akhter MS Hakamy A Humran A Hamali Y Jackson DE Hamali HA MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
description |
Abdullah A Mobarki,1 Gasim Dobie,1 Muhammad Saboor,1,2 Aymen M Madkhali,1 Mohammad S Akhter,1 Ali Hakamy,3 Adel Humran,4 Yousof Hamali,5 Denise E Jackson,6 Hassan A Hamali1 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia; 2Medical Research Center, Jazan University, Gizan, Saudi Arabia; 3Department of Respiratory Therapy, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia; 4Respiratory Care Department, King Fahad Central Hospital, Gizan, Saudi Arabia; 5Radiodiagnostics and Medical Imaging Department, Prince Sultan Medical City, Riyadh, Saudi Arabia; 6Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC, AustraliaCorrespondence: Hassan A HamaliDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, P.O. Box 1906, Gizan, 45142, Saudi ArabiaTel +966581155585Email hhamali@jazanu.edu.saObjective: The aims of the current study were to evaluate the importance of MPR and NLR as prognostic markers in ICU-admitted COVID-19 patients and to investigate the impact of COVID-19 on hematological and coagulation parameters in patients from Jazan region of Saudi Arabia.Methods: This retrospective study was conducted between October 2020 and January 2021 at King Fahad Central Hospital, Jazan region. Medical files, which included the results of complete blood count (CBC), calculated mean platelet volume to platelet count ratio (MPR) and neutrophils-to-lymphocytes ratio (NLR) parameters, coagulation profile and D-dimer test, of 96 (64 male and 32 female) COVID-19-infected patients admitted to the intensive care unit were reviewed. Associations between the test results and COVID-19 infection outcomes (discharged [DC] or passed away [PA]) were measured.Results: The results of the current study demonstrate overall significant differences in CBC parameters between PA group as compared to DC group (P < 0.05). The PA group had a significantly elevated MPR (10.15± 12.16 vs 4.04± 1.5; P < 0.01) and NLR (18.29± 19.82 vs 7.35± 9.68; P < 0.01) as compared to the DC group, suggesting an association between these parameters and mortality. Odds ratios analysis also showed that adjustment for demographic variables and comorbidities did not weaken the observed association.Conclusion: Elevated MPR and NLR are associated with poor prognosis in COVID-19 patients and could be useful as therapy management indicators.Keywords: COVID-19, NLR, MPR, ICU, CBC, mortality |
format |
article |
author |
Mobarki AA Dobie G Saboor M Madkhali AM Akhter MS Hakamy A Humran A Hamali Y Jackson DE Hamali HA |
author_facet |
Mobarki AA Dobie G Saboor M Madkhali AM Akhter MS Hakamy A Humran A Hamali Y Jackson DE Hamali HA |
author_sort |
Mobarki AA |
title |
MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
title_short |
MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
title_full |
MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
title_fullStr |
MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
title_full_unstemmed |
MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia |
title_sort |
mpr and nlr as prognostic markers in icu-admitted patients with covid-19 in jazan, saudi arabia |
publisher |
Dove Medical Press |
publishDate |
2021 |
url |
https://doaj.org/article/e3e52dd0ae5847ffa1c557e74bbaea6b |
work_keys_str_mv |
AT mobarkiaa mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT dobieg mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT saboorm mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT madkhaliam mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT akhterms mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT hakamya mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT humrana mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT hamaliy mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT jacksonde mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia AT hamaliha mprandnlrasprognosticmarkersinicuadmittedpatientswithcovid19injazansaudiarabia |
_version_ |
1718416186274742272 |