Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test

Abstract White spot syndrome virus (WSSV) causes major worldwide losses in shrimp aquaculture. The development of resistant shrimp populations is an attractive option for management of the disease. However, heritability for WSSV resistance is generally low and genetic improvement by conventional sel...

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Autores principales:	Marie Lillehammer, Rama Bangera, Marcela Salazar, Sergio Vela, Edna C. Erazo, Andres Suarez, James Cock, Morten Rye, Nicholas Andrew Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3e6a3349500486090a7ee0d8ddf1d39
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spelling	oai:doaj.org-article:e3e6a3349500486090a7ee0d8ddf1d392021-12-02T12:33:53ZGenomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test10.1038/s41598-020-77580-32045-2322https://doaj.org/article/e3e6a3349500486090a7ee0d8ddf1d392020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77580-3https://doaj.org/toc/2045-2322Abstract White spot syndrome virus (WSSV) causes major worldwide losses in shrimp aquaculture. The development of resistant shrimp populations is an attractive option for management of the disease. However, heritability for WSSV resistance is generally low and genetic improvement by conventional selection has been slow. This study was designed to determine the power and accuracy of genomic selection to improve WSSV resistance in Litopenaeus vannamei. Shrimp were experimentally challenged with WSSV and resistance was evaluated as dead or alive (DOA) 23 days after infestation. All shrimp in the challenge test were genotyped for 18,643 single nucleotide polymorphisms. Breeding candidates (G0) were ranked on genomic breeding values for WSSV resistance. Two G1 populations were produced, one from G0 breeders with high and the other with low estimated breeding values. A third population was produced from “random” mating of parent stock. The average survival was 25% in the low, 38% in the random and 51% in the high-genomic breeding value groups. Genomic heritability for DOA (0.41 in G1) was high for this type of trait. The realised genetic gain and high heritability clearly demonstrates large potential for further genetic improvement of WSSV resistance in the evaluated L. vannamei population using genomic selection.Marie LillehammerRama BangeraMarcela SalazarSergio VelaEdna C. ErazoAndres SuarezJames CockMorten RyeNicholas Andrew RobinsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Lillehammer Rama Bangera Marcela Salazar Sergio Vela Edna C. Erazo Andres Suarez James Cock Morten Rye Nicholas Andrew Robinson Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
description	Abstract White spot syndrome virus (WSSV) causes major worldwide losses in shrimp aquaculture. The development of resistant shrimp populations is an attractive option for management of the disease. However, heritability for WSSV resistance is generally low and genetic improvement by conventional selection has been slow. This study was designed to determine the power and accuracy of genomic selection to improve WSSV resistance in Litopenaeus vannamei. Shrimp were experimentally challenged with WSSV and resistance was evaluated as dead or alive (DOA) 23 days after infestation. All shrimp in the challenge test were genotyped for 18,643 single nucleotide polymorphisms. Breeding candidates (G0) were ranked on genomic breeding values for WSSV resistance. Two G1 populations were produced, one from G0 breeders with high and the other with low estimated breeding values. A third population was produced from “random” mating of parent stock. The average survival was 25% in the low, 38% in the random and 51% in the high-genomic breeding value groups. Genomic heritability for DOA (0.41 in G1) was high for this type of trait. The realised genetic gain and high heritability clearly demonstrates large potential for further genetic improvement of WSSV resistance in the evaluated L. vannamei population using genomic selection.
format	article
author	Marie Lillehammer Rama Bangera Marcela Salazar Sergio Vela Edna C. Erazo Andres Suarez James Cock Morten Rye Nicholas Andrew Robinson
author_facet	Marie Lillehammer Rama Bangera Marcela Salazar Sergio Vela Edna C. Erazo Andres Suarez James Cock Morten Rye Nicholas Andrew Robinson
author_sort	Marie Lillehammer
title	Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
title_short	Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
title_full	Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
title_fullStr	Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
title_full_unstemmed	Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
title_sort	genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e3e6a3349500486090a7ee0d8ddf1d39
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Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test

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