Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome

Abstract The objective of this study was to evaluate the effects of diabetes mellitus (DM) on the rate of carpal tunnel release (CTR) using a large nationwide cohort in Korea and to identify risk factors, including comorbidities and socioeconomic status (SES), associated with CTR. Patients with a pr...

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Autores principales:	Jaeyong Shin, Yong Wook Kim, Sang Chul Lee, Seung Nam Yang, Jee Suk Chang, Seo Yeon Yoon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3e6d63334de4ad48262bf23b38082f0
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spelling	oai:doaj.org-article:e3e6d63334de4ad48262bf23b38082f02021-12-02T18:49:36ZEffects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome10.1038/s41598-021-95316-92045-2322https://doaj.org/article/e3e6d63334de4ad48262bf23b38082f02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95316-9https://doaj.org/toc/2045-2322Abstract The objective of this study was to evaluate the effects of diabetes mellitus (DM) on the rate of carpal tunnel release (CTR) using a large nationwide cohort in Korea and to identify risk factors, including comorbidities and socioeconomic status (SES), associated with CTR. Patients with a primary or secondary diagnosis of carpal tunnel syndrome (CTS; ICD-10 code: G560) were selected and divided into two groups according to the presence of DM. A Cox proportional hazard model was used to assess the rate of CTR between the two groups. To evaluate the influence of demographic factors, comorbidities, and SES on CTR, multivariate Cox proportional hazard regression models were used to adjust for confounding variables. In total, 12,419 patients with CTS were included in the study: 2487 in DM cohort and 9932 in non-DM cohort. DM duration was negatively related with the rate of CTR (HR = 0.89, 95% CI 0.87–0.91) in CTS patients with DM. The rate of CTR was decreased in patients with DM compared to those without DM in the unadjusted model; however, after adjusting for comorbidities, DM had no significant effect on the rate of CTR. Female sex (HR = 1.50, 95% CI 1.36–1.67) correlated with the rate of CTR, and an inverse relationship between the number of comorbidities and CTR was found (p < 0.001) irrespective of DM. Diabetic polyneuropathy (DPN) was not associated with CTR, and we did not find any factors correlating with CTR in DPN patients. We found that CTS patients with more comorbidities or combined with a longer duration of DM were undertreated in real-word practice. Actual outcomes of CTR in CTS patents with various comorbidities should be investigated in future studies for optimal management of CTS.Jaeyong ShinYong Wook KimSang Chul LeeSeung Nam YangJee Suk ChangSeo Yeon YoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaeyong Shin Yong Wook Kim Sang Chul Lee Seung Nam Yang Jee Suk Chang Seo Yeon Yoon Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
description	Abstract The objective of this study was to evaluate the effects of diabetes mellitus (DM) on the rate of carpal tunnel release (CTR) using a large nationwide cohort in Korea and to identify risk factors, including comorbidities and socioeconomic status (SES), associated with CTR. Patients with a primary or secondary diagnosis of carpal tunnel syndrome (CTS; ICD-10 code: G560) were selected and divided into two groups according to the presence of DM. A Cox proportional hazard model was used to assess the rate of CTR between the two groups. To evaluate the influence of demographic factors, comorbidities, and SES on CTR, multivariate Cox proportional hazard regression models were used to adjust for confounding variables. In total, 12,419 patients with CTS were included in the study: 2487 in DM cohort and 9932 in non-DM cohort. DM duration was negatively related with the rate of CTR (HR = 0.89, 95% CI 0.87–0.91) in CTS patients with DM. The rate of CTR was decreased in patients with DM compared to those without DM in the unadjusted model; however, after adjusting for comorbidities, DM had no significant effect on the rate of CTR. Female sex (HR = 1.50, 95% CI 1.36–1.67) correlated with the rate of CTR, and an inverse relationship between the number of comorbidities and CTR was found (p < 0.001) irrespective of DM. Diabetic polyneuropathy (DPN) was not associated with CTR, and we did not find any factors correlating with CTR in DPN patients. We found that CTS patients with more comorbidities or combined with a longer duration of DM were undertreated in real-word practice. Actual outcomes of CTR in CTS patents with various comorbidities should be investigated in future studies for optimal management of CTS.
format	article
author	Jaeyong Shin Yong Wook Kim Sang Chul Lee Seung Nam Yang Jee Suk Chang Seo Yeon Yoon
author_facet	Jaeyong Shin Yong Wook Kim Sang Chul Lee Seung Nam Yang Jee Suk Chang Seo Yeon Yoon
author_sort	Jaeyong Shin
title	Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
title_short	Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
title_full	Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
title_fullStr	Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
title_full_unstemmed	Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
title_sort	effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3e6d63334de4ad48262bf23b38082f0
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Effects of diabetes mellitus on the rate of carpal tunnel release in patients with carpal tunnel syndrome

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