Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study

Background: No consensus exists regarding the hemoglobin (Hb) values that define postpartum anemia. Knowledge is currently lacking regarding prescription and consumption practices, which prevents evaluating the rational use of iron supplementation postpartum. Aim: In this study, our objective was to...

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Autores principales: Regina Ruiz de Viñaspre-Hernández, José Antonio García-Erce, Francisco José Rodríguez-Velasco, Vicente Gea-Caballero, Teresa Sufrate-Sorzano, María Elena Garrote-Cámara, Raquel Urra-Martínez, Raúl Juárez-Vela, Michał Czapla, Iván Santolalla-Arnedo
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/e3ecb4dea02d4e0998e5c31e1c61fb73
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spelling oai:doaj.org-article:e3ecb4dea02d4e0998e5c31e1c61fb732021-11-11T17:49:05ZVariability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study10.3390/jcm102152122077-0383https://doaj.org/article/e3ecb4dea02d4e0998e5c31e1c61fb732021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5212https://doaj.org/toc/2077-0383Background: No consensus exists regarding the hemoglobin (Hb) values that define postpartum anemia. Knowledge is currently lacking regarding prescription and consumption practices, which prevents evaluating the rational use of iron supplementation postpartum. Aim: In this study, our objective was to describe this practice and analyze its association with maternal health outcomes. Methods: A prospective observational study was conducted with 1010 women aged between 18 and 50. The hemoglobin value on the first postpartum day; the prescription schedule at hospital discharge; iron consumption; and data on hemoglobin, serum ferritin, maternal fatigue, type of breastfeeding, and perceived health six weeks after delivery were collected. Findings: Oral iron was prescribed to 98.1% of mothers with anemia and 75.8% without anemia. At the same Hb value, the maximum amount of total iron prescribed was between 8 and 10 times greater than the minimum amount. Iron intake was significantly lower than prescribed (<i>p</i> < 0.01). At six weeks, anemic mothers who took iron presented a 3.6-, 3-, and 2.4-times lower probability of iron deficiency, anemia, and abandoning breastfeeding, respectively. Discussion: Postpartum iron intake shows a protective effect on iron deficiency and anemia at six weeks, but not on fatigue or self-perceived health level. Conclusion: We conclude that there is wide variability in the prescription regimen. Oral iron supplementation can benefit mothers with anemia and harm those without. Subsequent studies should further explore the Hb figure that better discriminates the need for postpartum iron.Regina Ruiz de Viñaspre-HernándezJosé Antonio García-ErceFrancisco José Rodríguez-VelascoVicente Gea-CaballeroTeresa Sufrate-SorzanoMaría Elena Garrote-CámaraRaquel Urra-MartínezRaúl Juárez-VelaMichał CzaplaIván Santolalla-ArnedoMDPI AGarticleprescriptionmedicineironanemiagynecologyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5212, p 5212 (2021)
institution DOAJ
collection DOAJ
language EN
topic prescription
medicine
iron
anemia
gynecology
Medicine
R
spellingShingle prescription
medicine
iron
anemia
gynecology
Medicine
R
Regina Ruiz de Viñaspre-Hernández
José Antonio García-Erce
Francisco José Rodríguez-Velasco
Vicente Gea-Caballero
Teresa Sufrate-Sorzano
María Elena Garrote-Cámara
Raquel Urra-Martínez
Raúl Juárez-Vela
Michał Czapla
Iván Santolalla-Arnedo
Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
description Background: No consensus exists regarding the hemoglobin (Hb) values that define postpartum anemia. Knowledge is currently lacking regarding prescription and consumption practices, which prevents evaluating the rational use of iron supplementation postpartum. Aim: In this study, our objective was to describe this practice and analyze its association with maternal health outcomes. Methods: A prospective observational study was conducted with 1010 women aged between 18 and 50. The hemoglobin value on the first postpartum day; the prescription schedule at hospital discharge; iron consumption; and data on hemoglobin, serum ferritin, maternal fatigue, type of breastfeeding, and perceived health six weeks after delivery were collected. Findings: Oral iron was prescribed to 98.1% of mothers with anemia and 75.8% without anemia. At the same Hb value, the maximum amount of total iron prescribed was between 8 and 10 times greater than the minimum amount. Iron intake was significantly lower than prescribed (<i>p</i> < 0.01). At six weeks, anemic mothers who took iron presented a 3.6-, 3-, and 2.4-times lower probability of iron deficiency, anemia, and abandoning breastfeeding, respectively. Discussion: Postpartum iron intake shows a protective effect on iron deficiency and anemia at six weeks, but not on fatigue or self-perceived health level. Conclusion: We conclude that there is wide variability in the prescription regimen. Oral iron supplementation can benefit mothers with anemia and harm those without. Subsequent studies should further explore the Hb figure that better discriminates the need for postpartum iron.
format article
author Regina Ruiz de Viñaspre-Hernández
José Antonio García-Erce
Francisco José Rodríguez-Velasco
Vicente Gea-Caballero
Teresa Sufrate-Sorzano
María Elena Garrote-Cámara
Raquel Urra-Martínez
Raúl Juárez-Vela
Michał Czapla
Iván Santolalla-Arnedo
author_facet Regina Ruiz de Viñaspre-Hernández
José Antonio García-Erce
Francisco José Rodríguez-Velasco
Vicente Gea-Caballero
Teresa Sufrate-Sorzano
María Elena Garrote-Cámara
Raquel Urra-Martínez
Raúl Juárez-Vela
Michał Czapla
Iván Santolalla-Arnedo
author_sort Regina Ruiz de Viñaspre-Hernández
title Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
title_short Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
title_full Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
title_fullStr Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
title_full_unstemmed Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study
title_sort variability in oral iron prescription and the effect on spanish mothers’ health: a prospective longitudinal study
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/e3ecb4dea02d4e0998e5c31e1c61fb73
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