Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans

Abstract Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable...

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Autores principales:	Karolina Samekova, Christa Firbas, Johanna Irrgeher, Christine Opper, Thomas Prohaska, Anika Retzmann, Cornelius Tschegg, Claudia Meisslitzer, Anastassiya Tchaikovsky, Ghazaleh Gouya, Michael Freissmuth, Michael Wolzt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3ed057f9f0f42f99db1388f0e83ac53
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spelling	oai:doaj.org-article:e3ed057f9f0f42f99db1388f0e83ac532021-12-02T17:57:16ZConcomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans10.1038/s41598-021-94245-x2045-2322https://doaj.org/article/e3ed057f9f0f42f99db1388f0e83ac532021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94245-xhttps://doaj.org/toc/2045-2322Abstract Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope 204Pb as a tracer. In this randomized, placebo-controlled, double-blind, parallel-group study, 42 healthy participants were randomized to receive oral G-PUR 2.0 g, 2 * 2.0 g, or placebo, together with 2.5 µg of 204Pb in water. The enrichment of 204Pb caused by the tracer in blood and urine was measured by mass spectrometry. G-PUR was well tolerated. The mean maximum 204Pb enrichment of 0.505% of total blood lead was significantly higher (p < 0.0001) in the placebo group compared to G-PUR 2.0 g (0.073%) or G-PUR 2 * 2.0 g (0.057%) group. Normalized 204Pb AUC0-192 was 86.5, 11.9, and 8.5% * h without and with G-PUR 2.0 g, and G-PUR 2 * 2.0 g, respectively (p < 0.0001 vs. placebo). This smaller 204Pb exposure was paralleled by a reduced urinary excretion in subjects receiving G-PUR. Concomitant oral intake of purified clinoptilolite tuff reduced enteral uptake of 204Pb in healthy humans by approximately 90%. The reduced bioavailability is demonstrable by a decrease of 204Pb tracer enrichment in blood and urine. Trial registration: clinicaltrials.gov identifier: NCT04138693, registered 24/10/2019.Karolina SamekovaChrista FirbasJohanna IrrgeherChristine OpperThomas ProhaskaAnika RetzmannCornelius TscheggClaudia MeisslitzerAnastassiya TchaikovskyGhazaleh GouyaMichael FreissmuthMichael WolztNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karolina Samekova Christa Firbas Johanna Irrgeher Christine Opper Thomas Prohaska Anika Retzmann Cornelius Tschegg Claudia Meisslitzer Anastassiya Tchaikovsky Ghazaleh Gouya Michael Freissmuth Michael Wolzt Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
description	Abstract Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope 204Pb as a tracer. In this randomized, placebo-controlled, double-blind, parallel-group study, 42 healthy participants were randomized to receive oral G-PUR 2.0 g, 2 * 2.0 g, or placebo, together with 2.5 µg of 204Pb in water. The enrichment of 204Pb caused by the tracer in blood and urine was measured by mass spectrometry. G-PUR was well tolerated. The mean maximum 204Pb enrichment of 0.505% of total blood lead was significantly higher (p < 0.0001) in the placebo group compared to G-PUR 2.0 g (0.073%) or G-PUR 2 * 2.0 g (0.057%) group. Normalized 204Pb AUC0-192 was 86.5, 11.9, and 8.5% * h without and with G-PUR 2.0 g, and G-PUR 2 * 2.0 g, respectively (p < 0.0001 vs. placebo). This smaller 204Pb exposure was paralleled by a reduced urinary excretion in subjects receiving G-PUR. Concomitant oral intake of purified clinoptilolite tuff reduced enteral uptake of 204Pb in healthy humans by approximately 90%. The reduced bioavailability is demonstrable by a decrease of 204Pb tracer enrichment in blood and urine. Trial registration: clinicaltrials.gov identifier: NCT04138693, registered 24/10/2019.
format	article
author	Karolina Samekova Christa Firbas Johanna Irrgeher Christine Opper Thomas Prohaska Anika Retzmann Cornelius Tschegg Claudia Meisslitzer Anastassiya Tchaikovsky Ghazaleh Gouya Michael Freissmuth Michael Wolzt
author_facet	Karolina Samekova Christa Firbas Johanna Irrgeher Christine Opper Thomas Prohaska Anika Retzmann Cornelius Tschegg Claudia Meisslitzer Anastassiya Tchaikovsky Ghazaleh Gouya Michael Freissmuth Michael Wolzt
author_sort	Karolina Samekova
title	Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_short	Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_full	Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_fullStr	Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_full_unstemmed	Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_sort	concomitant oral intake of purified clinoptilolite tuff (g-pur) reduces enteral lead uptake in healthy humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3ed057f9f0f42f99db1388f0e83ac53
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Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans

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