Recent Developments and Aspects of Industrial Fluoroalkylation

Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced interm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matthias Keller, Florian Fischer, Andreas Locher, Helfried Neumann, Christoph Taeschler, Fei Ye, Shaoke Zhang
Formato:	article
Lenguaje:	DE EN FR
Publicado:	Swiss Chemical Society 2021
Materias:	catalysis dithionite fluoroalkylation industry sulfinatodehalogenation Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e3ed9331d4594928b4007820c51cbb82
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3ed9331d4594928b4007820c51cbb82
record_format	dspace
spelling	oai:doaj.org-article:e3ed9331d4594928b4007820c51cbb822021-11-26T09:57:32ZRecent Developments and Aspects of Industrial Fluoroalkylation10.2533/chimia.2021.9230009-42932673-2424https://doaj.org/article/e3ed9331d4594928b4007820c51cbb822021-11-01T00:00:00Zhttps://doaj.org/toc/0009-4293https://doaj.org/toc/2673-2424Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale process. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytically activated fluoroalkylation protocols were considered for industrial large-scale applications.Matthias KellerFlorian FischerAndreas LocherHelfried NeumannChristoph TaeschlerFei YeShaoke ZhangSwiss Chemical SocietyarticlecatalysisdithionitefluoroalkylationindustrysulfinatodehalogenationChemistryQD1-999DEENFRCHIMIA, Vol 75, Iss 11, Pp 923-935 (2021)
institution	DOAJ
collection	DOAJ
language	DE EN FR
topic	catalysis dithionite fluoroalkylation industry sulfinatodehalogenation Chemistry QD1-999
spellingShingle	catalysis dithionite fluoroalkylation industry sulfinatodehalogenation Chemistry QD1-999 Matthias Keller Florian Fischer Andreas Locher Helfried Neumann Christoph Taeschler Fei Ye Shaoke Zhang Recent Developments and Aspects of Industrial Fluoroalkylation
description	Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale process. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytically activated fluoroalkylation protocols were considered for industrial large-scale applications.
format	article
author	Matthias Keller Florian Fischer Andreas Locher Helfried Neumann Christoph Taeschler Fei Ye Shaoke Zhang
author_facet	Matthias Keller Florian Fischer Andreas Locher Helfried Neumann Christoph Taeschler Fei Ye Shaoke Zhang
author_sort	Matthias Keller
title	Recent Developments and Aspects of Industrial Fluoroalkylation
title_short	Recent Developments and Aspects of Industrial Fluoroalkylation
title_full	Recent Developments and Aspects of Industrial Fluoroalkylation
title_fullStr	Recent Developments and Aspects of Industrial Fluoroalkylation
title_full_unstemmed	Recent Developments and Aspects of Industrial Fluoroalkylation
title_sort	recent developments and aspects of industrial fluoroalkylation
publisher	Swiss Chemical Society
publishDate	2021
url	https://doaj.org/article/e3ed9331d4594928b4007820c51cbb82
work_keys_str_mv	AT matthiaskeller recentdevelopmentsandaspectsofindustrialfluoroalkylation AT florianfischer recentdevelopmentsandaspectsofindustrialfluoroalkylation AT andreaslocher recentdevelopmentsandaspectsofindustrialfluoroalkylation AT helfriedneumann recentdevelopmentsandaspectsofindustrialfluoroalkylation AT christophtaeschler recentdevelopmentsandaspectsofindustrialfluoroalkylation AT feiye recentdevelopmentsandaspectsofindustrialfluoroalkylation AT shaokezhang recentdevelopmentsandaspectsofindustrialfluoroalkylation
_version_	1718409690490077184

Recent Developments and Aspects of Industrial Fluoroalkylation

Ejemplares similares