An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors

Cancer research: Mathematical model describes mechanics of cell coordination In many cancers, spreading and the formation of metastasis involve the coordinated migration of many cells. An interdisciplinary team of researchers from Heidelberg and Frankfurt studied the collective movement of cultured...

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Autores principales:	Damian Stichel, Alistair M. Middleton, Benedikt F. Müller, Sofia Depner, Ursula Klingmüller, Kai Breuhahn, Franziska Matthäus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e3f4b3dd96e54f9fb079e31befe0f1d1
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spelling	oai:doaj.org-article:e3f4b3dd96e54f9fb079e31befe0f1d12021-12-02T16:09:11ZAn individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors10.1038/s41540-017-0006-32056-7189https://doaj.org/article/e3f4b3dd96e54f9fb079e31befe0f1d12017-03-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0006-3https://doaj.org/toc/2056-7189Cancer research: Mathematical model describes mechanics of cell coordination In many cancers, spreading and the formation of metastasis involve the coordinated migration of many cells. An interdisciplinary team of researchers from Heidelberg and Frankfurt studied the collective movement of cultured lung cancer cells subject to chemical stimulation. Based on extensive data analysis a mathematical model was developed to explain the variety of migration behaviors observed under different treatments. The model describes the mechanics of compression, stretch, cell elasticity and force-regulated active motion—which in sum lead to coordination within large cell groups. Simulations demonstrate how these mechanical features affect cell coordination and collective behavior. In tests of potential medical treatment strategies, the model can be used to predict the effects of the drug on specific mechanical properties of single cells.Damian StichelAlistair M. MiddletonBenedikt F. MüllerSofia DepnerUrsula KlingmüllerKai BreuhahnFranziska MatthäusNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Damian Stichel Alistair M. Middleton Benedikt F. Müller Sofia Depner Ursula Klingmüller Kai Breuhahn Franziska Matthäus An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
description	Cancer research: Mathematical model describes mechanics of cell coordination In many cancers, spreading and the formation of metastasis involve the coordinated migration of many cells. An interdisciplinary team of researchers from Heidelberg and Frankfurt studied the collective movement of cultured lung cancer cells subject to chemical stimulation. Based on extensive data analysis a mathematical model was developed to explain the variety of migration behaviors observed under different treatments. The model describes the mechanics of compression, stretch, cell elasticity and force-regulated active motion—which in sum lead to coordination within large cell groups. Simulations demonstrate how these mechanical features affect cell coordination and collective behavior. In tests of potential medical treatment strategies, the model can be used to predict the effects of the drug on specific mechanical properties of single cells.
format	article
author	Damian Stichel Alistair M. Middleton Benedikt F. Müller Sofia Depner Ursula Klingmüller Kai Breuhahn Franziska Matthäus
author_facet	Damian Stichel Alistair M. Middleton Benedikt F. Müller Sofia Depner Ursula Klingmüller Kai Breuhahn Franziska Matthäus
author_sort	Damian Stichel
title	An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
title_short	An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
title_full	An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
title_fullStr	An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
title_full_unstemmed	An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
title_sort	individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3f4b3dd96e54f9fb079e31befe0f1d1
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An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors

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