A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)

Background: A major depressive episode (MDE) is typically self-rated by screening forms identifying probable MDE (pMDE). This population-based cross-sectional questionnaire study examined the prevalence rates of pMDE identified by the PHQ-9 screener in long-term survivors of childhood and adolescenc...

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Autores principales:	Alv A. Dahl, Cecilie Essholt Kiserud, Sophie D. Fosså, Jon Håvard Loge, Kristin Valborg Reinertsen, Ellen Ruud, Hanne C. Lie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	major depressive episode PHQ-9 childhood, adolescence and young adult cancer survivors cancer treatment cross-sectional study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e3f501ca84104e0aa71328b12d79fe13
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spelling	oai:doaj.org-article:e3f501ca84104e0aa71328b12d79fe132021-11-25T17:04:08ZA Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)10.3390/cancers132258002072-6694https://doaj.org/article/e3f501ca84104e0aa71328b12d79fe132021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5800https://doaj.org/toc/2072-6694Background: A major depressive episode (MDE) is typically self-rated by screening forms identifying probable MDE (pMDE). This population-based cross-sectional questionnaire study examined the prevalence rates of pMDE identified by the PHQ-9 screener in long-term survivors of childhood and adolescence (CACSs) and young adult cancer (YACSs) and a normative sample (NORMs). Methods: Data from 488 CACSs, 1202 YACSs, and 1453 NORMs were analyzed, and pMDE was defined both by cut-off ≥10 on the total PHQ-9 score and by an algorithm. Results: The prevalence rates of pMDE among CACSs were 21.5%, 16.6% in YACSs, and 9.2% among NORMs using the cut-off definition. With the algorithm, the prevalence rates of pMDE were 8.0% among CACSs, 8.1% among YACSs, and 3.9% among NORMs. Independent of definition, CACSs and YACSs had significantly increased prevalence rates of pMDE compared to NORMs. Psychosocial factors and self-rated health were significantly associated with both definitions of pMDE in multivariable analyses, while survivor groups, cancer types, and adverse events were not. Conclusion: Since pMDE has negative health consequences and is amenable to treatment, healthcare providers should be attentive and screen for pMDE in young cancer survivors. For PHQ-9, the preferred type of definition of pMDE should be determined.Alv A. DahlCecilie Essholt KiserudSophie D. FossåJon Håvard LogeKristin Valborg ReinertsenEllen RuudHanne C. LieMDPI AGarticlemajor depressive episodePHQ-9childhood, adolescence and young adult cancer survivorscancer treatmentcross-sectional studyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5800, p 5800 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive episode PHQ-9 childhood, adolescence and young adult cancer survivors cancer treatment cross-sectional study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	major depressive episode PHQ-9 childhood, adolescence and young adult cancer survivors cancer treatment cross-sectional study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
description	Background: A major depressive episode (MDE) is typically self-rated by screening forms identifying probable MDE (pMDE). This population-based cross-sectional questionnaire study examined the prevalence rates of pMDE identified by the PHQ-9 screener in long-term survivors of childhood and adolescence (CACSs) and young adult cancer (YACSs) and a normative sample (NORMs). Methods: Data from 488 CACSs, 1202 YACSs, and 1453 NORMs were analyzed, and pMDE was defined both by cut-off ≥10 on the total PHQ-9 score and by an algorithm. Results: The prevalence rates of pMDE among CACSs were 21.5%, 16.6% in YACSs, and 9.2% among NORMs using the cut-off definition. With the algorithm, the prevalence rates of pMDE were 8.0% among CACSs, 8.1% among YACSs, and 3.9% among NORMs. Independent of definition, CACSs and YACSs had significantly increased prevalence rates of pMDE compared to NORMs. Psychosocial factors and self-rated health were significantly associated with both definitions of pMDE in multivariable analyses, while survivor groups, cancer types, and adverse events were not. Conclusion: Since pMDE has negative health consequences and is amenable to treatment, healthcare providers should be attentive and screen for pMDE in young cancer survivors. For PHQ-9, the preferred type of definition of pMDE should be determined.
format	article
author	Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie
author_facet	Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie
author_sort	Alv A. Dahl
title	A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
title_short	A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
title_full	A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
title_fullStr	A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
title_full_unstemmed	A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
title_sort	controlled study of major depressive episodes in long-term childhood, adolescence, and young adult cancer survivors (the nor-cayacs study)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e3f501ca84104e0aa71328b12d79fe13
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A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)

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