Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues

Summary: Chemotaxis is ubiquitous in many biological processes, but it still remains elusive how cells sense and decipher multiple chemical cues. In this study, we postulate a hypothesis that the chemotactic performance of cells under complex cues is regulated by the signal processing capacity of th...

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Autores principales:	Hye-ran Moon, Soutick Saha, Andrew Mugler, Bumsoo Han
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cell biology Mathematical biosciences Systems biology Science Q
Acceso en línea:	https://doaj.org/article/e3f50d54946f482c88c8828f949d51e5
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id	oai:doaj.org-article:e3f50d54946f482c88c8828f949d51e5
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spelling	oai:doaj.org-article:e3f50d54946f482c88c8828f949d51e52021-11-20T05:08:47ZSignal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues2589-004210.1016/j.isci.2021.103242https://doaj.org/article/e3f50d54946f482c88c8828f949d51e52021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012104https://doaj.org/toc/2589-0042Summary: Chemotaxis is ubiquitous in many biological processes, but it still remains elusive how cells sense and decipher multiple chemical cues. In this study, we postulate a hypothesis that the chemotactic performance of cells under complex cues is regulated by the signal processing capacity of the cellular sensory machinery. The underlying rationale is that cells in vivo should be able to sense and process multiple chemical cues, whose magnitude and compositions are entangled, to determine their migration direction. We experimentally show that the combination of transforming growth factor-β and epidermal growth factor suppresses the chemotactic performance of cancer cells using independent receptors to sense the two cues. Based on this observation, we develop a biophysical framework suggesting that the antagonism is caused by the saturation of the signal processing capacity but not by the mutual repression. Our framework suggests the significance of the signal processing capacity in the cellular sensory machinery.Hye-ran MoonSoutick SahaAndrew MuglerBumsoo HanElsevierarticleCell biologyMathematical biosciencesSystems biologyScienceQENiScience, Vol 24, Iss 11, Pp 103242- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell biology Mathematical biosciences Systems biology Science Q
spellingShingle	Cell biology Mathematical biosciences Systems biology Science Q Hye-ran Moon Soutick Saha Andrew Mugler Bumsoo Han Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
description	Summary: Chemotaxis is ubiquitous in many biological processes, but it still remains elusive how cells sense and decipher multiple chemical cues. In this study, we postulate a hypothesis that the chemotactic performance of cells under complex cues is regulated by the signal processing capacity of the cellular sensory machinery. The underlying rationale is that cells in vivo should be able to sense and process multiple chemical cues, whose magnitude and compositions are entangled, to determine their migration direction. We experimentally show that the combination of transforming growth factor-β and epidermal growth factor suppresses the chemotactic performance of cancer cells using independent receptors to sense the two cues. Based on this observation, we develop a biophysical framework suggesting that the antagonism is caused by the saturation of the signal processing capacity but not by the mutual repression. Our framework suggests the significance of the signal processing capacity in the cellular sensory machinery.
format	article
author	Hye-ran Moon Soutick Saha Andrew Mugler Bumsoo Han
author_facet	Hye-ran Moon Soutick Saha Andrew Mugler Bumsoo Han
author_sort	Hye-ran Moon
title	Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
title_short	Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
title_full	Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
title_fullStr	Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
title_full_unstemmed	Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
title_sort	signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e3f50d54946f482c88c8828f949d51e5
work_keys_str_mv	AT hyeranmoon signalprocessingcapacityofthecellularsensorymachineryregulatestheaccuracyofchemotaxisundercomplexcues AT souticksaha signalprocessingcapacityofthecellularsensorymachineryregulatestheaccuracyofchemotaxisundercomplexcues AT andrewmugler signalprocessingcapacityofthecellularsensorymachineryregulatestheaccuracyofchemotaxisundercomplexcues AT bumsoohan signalprocessingcapacityofthecellularsensorymachineryregulatestheaccuracyofchemotaxisundercomplexcues
_version_	1718419573227651072

Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues

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