Collective dynamics of gene expression in cell populations.

The phenotypic state of the cell is commonly thought to be determined by the set of expressed genes. However, given the apparent complexity of genetic networks, it remains open what processes stabilize a particular phenotypic state. Moreover, it is not clear how unique is the mapping between the vec...

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Autores principales:	Elad Stolovicki, Erez Braun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3f5281cfb4b4655bb3068262e582a82
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spelling	oai:doaj.org-article:e3f5281cfb4b4655bb3068262e582a822021-11-18T06:52:02ZCollective dynamics of gene expression in cell populations.1932-620310.1371/journal.pone.0020530https://doaj.org/article/e3f5281cfb4b4655bb3068262e582a822011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698278/?tool=EBIhttps://doaj.org/toc/1932-6203The phenotypic state of the cell is commonly thought to be determined by the set of expressed genes. However, given the apparent complexity of genetic networks, it remains open what processes stabilize a particular phenotypic state. Moreover, it is not clear how unique is the mapping between the vector of expressed genes and the cell's phenotypic state. To gain insight on these issues, we study here the expression dynamics of metabolically essential genes in twin cell populations. We show that two yeast cell populations derived from a single steady-state mother population and exhibiting a similar growth phenotype in response to an environmental challenge, displayed diverse expression patterns of essential genes. The observed diversity in the mean expression between populations could not result from stochastic cell-to-cell variability, which would be averaged out in our large cell populations. Remarkably, within a population, sets of expressed genes exhibited coherent dynamics over many generations. Thus, the emerging gene expression patterns resulted from collective population dynamics. It suggests that in a wide range of biological contexts, gene expression reflects a self-organization process coupled to population-environment dynamics.Elad StolovickiErez BraunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20530 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elad Stolovicki Erez Braun Collective dynamics of gene expression in cell populations.
description	The phenotypic state of the cell is commonly thought to be determined by the set of expressed genes. However, given the apparent complexity of genetic networks, it remains open what processes stabilize a particular phenotypic state. Moreover, it is not clear how unique is the mapping between the vector of expressed genes and the cell's phenotypic state. To gain insight on these issues, we study here the expression dynamics of metabolically essential genes in twin cell populations. We show that two yeast cell populations derived from a single steady-state mother population and exhibiting a similar growth phenotype in response to an environmental challenge, displayed diverse expression patterns of essential genes. The observed diversity in the mean expression between populations could not result from stochastic cell-to-cell variability, which would be averaged out in our large cell populations. Remarkably, within a population, sets of expressed genes exhibited coherent dynamics over many generations. Thus, the emerging gene expression patterns resulted from collective population dynamics. It suggests that in a wide range of biological contexts, gene expression reflects a self-organization process coupled to population-environment dynamics.
format	article
author	Elad Stolovicki Erez Braun
author_facet	Elad Stolovicki Erez Braun
author_sort	Elad Stolovicki
title	Collective dynamics of gene expression in cell populations.
title_short	Collective dynamics of gene expression in cell populations.
title_full	Collective dynamics of gene expression in cell populations.
title_fullStr	Collective dynamics of gene expression in cell populations.
title_full_unstemmed	Collective dynamics of gene expression in cell populations.
title_sort	collective dynamics of gene expression in cell populations.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e3f5281cfb4b4655bb3068262e582a82
work_keys_str_mv	AT eladstolovicki collectivedynamicsofgeneexpressionincellpopulations AT erezbraun collectivedynamicsofgeneexpressionincellpopulations
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Collective dynamics of gene expression in cell populations.

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