Intrinsic timescales across the basal ganglia

Abstract Recent studies have shown that temporal stability of the neuronal activity over time can be estimated by the structure of the spike-count autocorrelation of neuronal populations. This estimation, called the intrinsic timescale, has been computed for several cortical areas and can be used to...

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Autores principales:	Simon Nougaret, Valeria Fascianelli, Sabrina Ravel, Aldo Genovesio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3f7e98cb8f7486dba07a82748a7c5d4
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spelling	oai:doaj.org-article:e3f7e98cb8f7486dba07a82748a7c5d42021-11-08T10:48:12ZIntrinsic timescales across the basal ganglia10.1038/s41598-021-00512-22045-2322https://doaj.org/article/e3f7e98cb8f7486dba07a82748a7c5d42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00512-2https://doaj.org/toc/2045-2322Abstract Recent studies have shown that temporal stability of the neuronal activity over time can be estimated by the structure of the spike-count autocorrelation of neuronal populations. This estimation, called the intrinsic timescale, has been computed for several cortical areas and can be used to propose a cortical hierarchy reflecting a scale of temporal receptive windows between areas. In this study, we performed an autocorrelation analysis on neuronal populations of three basal ganglia (BG) nuclei, including the striatum and the subthalamic nucleus (STN), the input structures of the BG, and the external globus pallidus (GPe). The analysis was performed during the baseline period of a motivational visuomotor task in which monkeys had to apply different amounts of force to receive different amounts of reward. We found that the striatum and the STN have longer intrinsic timescales than the GPe. Moreover, our results allow for the placement of these subcortical structures within the already-defined scale of cortical temporal receptive windows. Estimates of intrinsic timescales are important in adding further constraints in the development of computational models of the complex dynamics among these nuclei and throughout cortico-BG-thalamo-cortical loops.Simon NougaretValeria FascianelliSabrina RavelAldo GenovesioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon Nougaret Valeria Fascianelli Sabrina Ravel Aldo Genovesio Intrinsic timescales across the basal ganglia
description	Abstract Recent studies have shown that temporal stability of the neuronal activity over time can be estimated by the structure of the spike-count autocorrelation of neuronal populations. This estimation, called the intrinsic timescale, has been computed for several cortical areas and can be used to propose a cortical hierarchy reflecting a scale of temporal receptive windows between areas. In this study, we performed an autocorrelation analysis on neuronal populations of three basal ganglia (BG) nuclei, including the striatum and the subthalamic nucleus (STN), the input structures of the BG, and the external globus pallidus (GPe). The analysis was performed during the baseline period of a motivational visuomotor task in which monkeys had to apply different amounts of force to receive different amounts of reward. We found that the striatum and the STN have longer intrinsic timescales than the GPe. Moreover, our results allow for the placement of these subcortical structures within the already-defined scale of cortical temporal receptive windows. Estimates of intrinsic timescales are important in adding further constraints in the development of computational models of the complex dynamics among these nuclei and throughout cortico-BG-thalamo-cortical loops.
format	article
author	Simon Nougaret Valeria Fascianelli Sabrina Ravel Aldo Genovesio
author_facet	Simon Nougaret Valeria Fascianelli Sabrina Ravel Aldo Genovesio
author_sort	Simon Nougaret
title	Intrinsic timescales across the basal ganglia
title_short	Intrinsic timescales across the basal ganglia
title_full	Intrinsic timescales across the basal ganglia
title_fullStr	Intrinsic timescales across the basal ganglia
title_full_unstemmed	Intrinsic timescales across the basal ganglia
title_sort	intrinsic timescales across the basal ganglia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3f7e98cb8f7486dba07a82748a7c5d4
work_keys_str_mv	AT simonnougaret intrinsictimescalesacrossthebasalganglia AT valeriafascianelli intrinsictimescalesacrossthebasalganglia AT sabrinaravel intrinsictimescalesacrossthebasalganglia AT aldogenovesio intrinsictimescalesacrossthebasalganglia
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Intrinsic timescales across the basal ganglia

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