Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops

Abstract This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a total of 1282 glaucoma patients. Both the PD(+) group and the PD(−) group were evaluated using clinical data such as age, sex, dosing duration, presence of benzalkoni...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Myungjin Kim, Hyoju Jang, Seungsoo Rho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3f88d173aec4c2baf3a503b9d1d7a25
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3f88d173aec4c2baf3a503b9d1d7a25
record_format	dspace
spelling	oai:doaj.org-article:e3f88d173aec4c2baf3a503b9d1d7a252021-12-02T19:13:48ZRisk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops10.1038/s41598-021-97565-02045-2322https://doaj.org/article/e3f88d173aec4c2baf3a503b9d1d7a252021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97565-0https://doaj.org/toc/2045-2322Abstract This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a total of 1282 glaucoma patients. Both the PD(+) group and the PD(−) group were evaluated using clinical data such as age, sex, dosing duration, presence of benzalkonium chloride (BAK) in the formulation, ocular surgery history (e.g. cataract or glaucoma operations), height, weight, personal history of systemic hypertension, smoking, alcohol consumption, intraocular pressure, best-corrected visual acuity (BCVA), central corneal thickness, axial length, and visual field index (VFI). Univariate analyses showed that shorter dosing duration, higher rate of BAK-included cases, worse BCVA, worse VFI, more systemic hypertension history, and more ocular surgery history were more associated with the PD(+) group than the PD(−) group. The BAK(−) group showed a lower PD rate than the BAK-included group, which was supported by the Kaplan–Meier analysis (log-rank test, p = 0.0014). Multivariate analyses revealed that the probability of PD increased by 8 times if they had a history of ocular surgery and increased by 2.3% when the VFI decreased by 1% (Cox’s hazard regression test, p < 0.001). Therefore, a preservative-free dorzolamide/timolol can benefit the subjects for those who had ocular surgery or who have worse VFI.Myungjin KimHyoju JangSeungsoo RhoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myungjin Kim Hyoju Jang Seungsoo Rho Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
description	Abstract This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a total of 1282 glaucoma patients. Both the PD(+) group and the PD(−) group were evaluated using clinical data such as age, sex, dosing duration, presence of benzalkonium chloride (BAK) in the formulation, ocular surgery history (e.g. cataract or glaucoma operations), height, weight, personal history of systemic hypertension, smoking, alcohol consumption, intraocular pressure, best-corrected visual acuity (BCVA), central corneal thickness, axial length, and visual field index (VFI). Univariate analyses showed that shorter dosing duration, higher rate of BAK-included cases, worse BCVA, worse VFI, more systemic hypertension history, and more ocular surgery history were more associated with the PD(+) group than the PD(−) group. The BAK(−) group showed a lower PD rate than the BAK-included group, which was supported by the Kaplan–Meier analysis (log-rank test, p = 0.0014). Multivariate analyses revealed that the probability of PD increased by 8 times if they had a history of ocular surgery and increased by 2.3% when the VFI decreased by 1% (Cox’s hazard regression test, p < 0.001). Therefore, a preservative-free dorzolamide/timolol can benefit the subjects for those who had ocular surgery or who have worse VFI.
format	article
author	Myungjin Kim Hyoju Jang Seungsoo Rho
author_facet	Myungjin Kim Hyoju Jang Seungsoo Rho
author_sort	Myungjin Kim
title	Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
title_short	Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
title_full	Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
title_fullStr	Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
title_full_unstemmed	Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
title_sort	risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3f88d173aec4c2baf3a503b9d1d7a25
work_keys_str_mv	AT myungjinkim riskfactorsforperiorbitaldermatitisinpatientsusingdorzolamidetimololeyedrops AT hyojujang riskfactorsforperiorbitaldermatitisinpatientsusingdorzolamidetimololeyedrops AT seungsoorho riskfactorsforperiorbitaldermatitisinpatientsusingdorzolamidetimololeyedrops
_version_	1718377030489210880

Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops

Ejemplares similares