Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.

<h4>Objective</h4>The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS). Reports concerning their association with long-term outcome after an ACS are equivocal. The aim of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna Szpakowicz, Marek Kiliszek, Witold Pepinski, Ewa Waszkiewicz, Maria Franaszczyk, Małgorzata Skawronska, Rafal Ploski, Anna Niemcunowicz-Janica, Sławomir Dobrzycki, Grzegorz Opolski, Włodzimierz Jerzy Musial, Karol Adam Kaminski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3ff2e391f20463aaad88d3d6fdfc73a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3ff2e391f20463aaad88d3d6fdfc73a
record_format	dspace
spelling	oai:doaj.org-article:e3ff2e391f20463aaad88d3d6fdfc73a2021-11-25T06:05:34ZPolymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.1932-620310.1371/journal.pone.0104635https://doaj.org/article/e3ff2e391f20463aaad88d3d6fdfc73a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25105296/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS). Reports concerning their association with long-term outcome after an ACS are equivocal. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-elevation myocardial infarction (STEMI).<h4>Materials and methods</h4>We performed a retrospective analysis of data collected prospectively in 2 independent registries of consecutive patients with STEMI (derivation and validation group). Genotyping was performed with the TaqMan method. The analyzed end-point was total mortality.<h4>Results</h4>The derivation group comprised 589 patients: 25.3% female (n = 149), mean age 62.4 ± 12.0 years, total 5-year mortality 16.6% (n = 98). When all the study group was analyzed, no significant differences in mortality were found between the genotypes. However, in high-risk patients (GRACE risk score ≥ 155 points, n = 238), homozygotes associated with higher risk for ACS had significantly better 5-year survival compared to other genotypes. The hazard ratio associated with the high-risk genotype (a homozygote of high risk for ACS or a heterozygote) was: HR = 2.2 (1.15-4.2) for the rs10757278 polymorphism, HR = 2.7 (95% CI 1.3-5.4) for the rs4977574 one and HR = 2.3 (1.2-4.5) for the rs1333049 one (Cox proportional hazards model). Survival analysis in the validation group (n = 365) showed a clear trend towards better prognosis in GG homozygotes of the rs10757278 SNP, which confirms our initial results (p = 0.09, log-rank test).<h4>Conclusions</h4>The 9p21.3 locus is associated with 5-year mortality in high-risk patients with STEMI. The genotypes associated with higher risk for ACS show a protective effect in terms of further survival (instead of a deteriorating prognosis, as reported previously). This finding, due to the very high size of the effect, could potentially be applied to clinical practice, if appropriate methods are elaborated.Anna SzpakowiczMarek KiliszekWitold PepinskiEwa WaszkiewiczMaria FranaszczykMałgorzata SkawronskaRafal PloskiAnna Niemcunowicz-JanicaSławomir DobrzyckiGrzegorz OpolskiWłodzimierz Jerzy MusialKarol Adam KaminskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104635 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Szpakowicz Marek Kiliszek Witold Pepinski Ewa Waszkiewicz Maria Franaszczyk Małgorzata Skawronska Rafal Ploski Anna Niemcunowicz-Janica Sławomir Dobrzycki Grzegorz Opolski Włodzimierz Jerzy Musial Karol Adam Kaminski Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
description	<h4>Objective</h4>The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS). Reports concerning their association with long-term outcome after an ACS are equivocal. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-elevation myocardial infarction (STEMI).<h4>Materials and methods</h4>We performed a retrospective analysis of data collected prospectively in 2 independent registries of consecutive patients with STEMI (derivation and validation group). Genotyping was performed with the TaqMan method. The analyzed end-point was total mortality.<h4>Results</h4>The derivation group comprised 589 patients: 25.3% female (n = 149), mean age 62.4 ± 12.0 years, total 5-year mortality 16.6% (n = 98). When all the study group was analyzed, no significant differences in mortality were found between the genotypes. However, in high-risk patients (GRACE risk score ≥ 155 points, n = 238), homozygotes associated with higher risk for ACS had significantly better 5-year survival compared to other genotypes. The hazard ratio associated with the high-risk genotype (a homozygote of high risk for ACS or a heterozygote) was: HR = 2.2 (1.15-4.2) for the rs10757278 polymorphism, HR = 2.7 (95% CI 1.3-5.4) for the rs4977574 one and HR = 2.3 (1.2-4.5) for the rs1333049 one (Cox proportional hazards model). Survival analysis in the validation group (n = 365) showed a clear trend towards better prognosis in GG homozygotes of the rs10757278 SNP, which confirms our initial results (p = 0.09, log-rank test).<h4>Conclusions</h4>The 9p21.3 locus is associated with 5-year mortality in high-risk patients with STEMI. The genotypes associated with higher risk for ACS show a protective effect in terms of further survival (instead of a deteriorating prognosis, as reported previously). This finding, due to the very high size of the effect, could potentially be applied to clinical practice, if appropriate methods are elaborated.
format	article
author	Anna Szpakowicz Marek Kiliszek Witold Pepinski Ewa Waszkiewicz Maria Franaszczyk Małgorzata Skawronska Rafal Ploski Anna Niemcunowicz-Janica Sławomir Dobrzycki Grzegorz Opolski Włodzimierz Jerzy Musial Karol Adam Kaminski
author_facet	Anna Szpakowicz Marek Kiliszek Witold Pepinski Ewa Waszkiewicz Maria Franaszczyk Małgorzata Skawronska Rafal Ploski Anna Niemcunowicz-Janica Sławomir Dobrzycki Grzegorz Opolski Włodzimierz Jerzy Musial Karol Adam Kaminski
author_sort	Anna Szpakowicz
title	Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
title_short	Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
title_full	Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
title_fullStr	Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
title_full_unstemmed	Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
title_sort	polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e3ff2e391f20463aaad88d3d6fdfc73a
work_keys_str_mv	AT annaszpakowicz polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT marekkiliszek polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT witoldpepinski polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT ewawaszkiewicz polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT mariafranaszczyk polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT małgorzataskawronska polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT rafalploski polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT annaniemcunowiczjanica polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT sławomirdobrzycki polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT grzegorzopolski polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT włodzimierzjerzymusial polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction AT karoladamkaminski polymorphismof9p213locusisassociatedwith5yearsurvivalinhighriskpatientswithmyocardialinfarction
_version_	1718414252750929920

Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.

Ejemplares similares