Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study

Abstract Background Some significant differences exist between the outcomes of left‐ and right‐sided colon cancer patients. The presence of nodal metastases is a critical prognostic factor, especially in the absence of distant metastasis. Our research studied the lymph nodes status of left‐ and righ...

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Autores principales:	Yadi Huang, Linlin Ji, Jialong Zhu, Xiaobei Mao, Siqi Sheng, Shuai Hao, Dan Xiang, Jiani Guo, Gongbo Fu, Mengxi Huang, Zengjie Lei, Xiaoyuan Chu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	left‐sided colon cancer lymph node status nomogram prognosis right‐sided colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e40479e2d31c4aa1aad2e55634eeafe4
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spelling	oai:doaj.org-article:e40479e2d31c4aa1aad2e55634eeafe42021-12-01T04:49:16ZLymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study2045-763410.1002/cam4.4357https://doaj.org/article/e40479e2d31c4aa1aad2e55634eeafe42021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4357https://doaj.org/toc/2045-7634Abstract Background Some significant differences exist between the outcomes of left‐ and right‐sided colon cancer patients. The presence of nodal metastases is a critical prognostic factor, especially in the absence of distant metastasis. Our research studied the lymph nodes status of left‐ and right‐sided colon cancer patients to determine the influence of this factor on prognosis. Methods Our data were obtained from the Surveillance, Epidemiology and End Results (SEER) database. We used the chi‐square test to analyze the clinicopathological characteristics. The X‐tile program was adopted to acquire optimal cutoff points of lymph node index. Kaplan–Meier curves were used to analyze prognosis and multivariate Cox regression models were performed to identify the independent factors associated with survival. Nomograms were built to predict the overall survival of patients, Harrell's C‐index and calibration plots were used to validate the nomograms. Results The study included 189,941 patients with colon cancer without metastasis (left 69,885, right 120,056) between 2004 and 2015. There are more patients with adequate examined lymph nodes in right‐sided. Lymph node status in patients with right colon cancer has a more significant impact on the risk of death. LODDS (C‐index: 0.583; AIC: 6875.4) was used to assess lymph node status. The nomograms showed that lymph node status was the main factor to predict the outcome in right‐sided colon patients. Conclusions The influence of lymph node status on predicting prognosis is significantly different between patients with left and right colon cancer without metastasis. The tumor site needs to be considered when lymph node status is used to assess the outcome of patients.Yadi HuangLinlin JiJialong ZhuXiaobei MaoSiqi ShengShuai HaoDan XiangJiani GuoGongbo FuMengxi HuangZengjie LeiXiaoyuan ChuWileyarticleleft‐sided colon cancerlymph node statusnomogramprognosisright‐sided colon cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8708-8719 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	left‐sided colon cancer lymph node status nomogram prognosis right‐sided colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	left‐sided colon cancer lymph node status nomogram prognosis right‐sided colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yadi Huang Linlin Ji Jialong Zhu Xiaobei Mao Siqi Sheng Shuai Hao Dan Xiang Jiani Guo Gongbo Fu Mengxi Huang Zengjie Lei Xiaoyuan Chu Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
description	Abstract Background Some significant differences exist between the outcomes of left‐ and right‐sided colon cancer patients. The presence of nodal metastases is a critical prognostic factor, especially in the absence of distant metastasis. Our research studied the lymph nodes status of left‐ and right‐sided colon cancer patients to determine the influence of this factor on prognosis. Methods Our data were obtained from the Surveillance, Epidemiology and End Results (SEER) database. We used the chi‐square test to analyze the clinicopathological characteristics. The X‐tile program was adopted to acquire optimal cutoff points of lymph node index. Kaplan–Meier curves were used to analyze prognosis and multivariate Cox regression models were performed to identify the independent factors associated with survival. Nomograms were built to predict the overall survival of patients, Harrell's C‐index and calibration plots were used to validate the nomograms. Results The study included 189,941 patients with colon cancer without metastasis (left 69,885, right 120,056) between 2004 and 2015. There are more patients with adequate examined lymph nodes in right‐sided. Lymph node status in patients with right colon cancer has a more significant impact on the risk of death. LODDS (C‐index: 0.583; AIC: 6875.4) was used to assess lymph node status. The nomograms showed that lymph node status was the main factor to predict the outcome in right‐sided colon patients. Conclusions The influence of lymph node status on predicting prognosis is significantly different between patients with left and right colon cancer without metastasis. The tumor site needs to be considered when lymph node status is used to assess the outcome of patients.
format	article
author	Yadi Huang Linlin Ji Jialong Zhu Xiaobei Mao Siqi Sheng Shuai Hao Dan Xiang Jiani Guo Gongbo Fu Mengxi Huang Zengjie Lei Xiaoyuan Chu
author_facet	Yadi Huang Linlin Ji Jialong Zhu Xiaobei Mao Siqi Sheng Shuai Hao Dan Xiang Jiani Guo Gongbo Fu Mengxi Huang Zengjie Lei Xiaoyuan Chu
author_sort	Yadi Huang
title	Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
title_short	Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
title_full	Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
title_fullStr	Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
title_full_unstemmed	Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study
title_sort	lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: a seer population‐based study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e40479e2d31c4aa1aad2e55634eeafe4
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Lymph node status and its impact on the prognosis of left‐sided and right‐sided colon cancer: A SEER population‐based study

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