Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.

Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that include increased disease severity in pregnant women, decreased fetal viability, intra-uterine growth retardation, low birth weight and infant mortality. The physiopathology of malaria in pregnancy is difficult...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rita Neres, Claudio R F Marinho, Lígia A Gonçalves, Manuela Beirão Catarino, Carlos Penha-Gonçalves
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e40648fa3f1244e0b3e7e7cc308f7a84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e40648fa3f1244e0b3e7e7cc308f7a84
record_format	dspace
spelling	oai:doaj.org-article:e40648fa3f1244e0b3e7e7cc308f7a842021-11-25T06:13:23ZPregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.1932-620310.1371/journal.pone.0001608https://doaj.org/article/e40648fa3f1244e0b3e7e7cc308f7a842008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18270595/?tool=EBIhttps://doaj.org/toc/1932-6203Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that include increased disease severity in pregnant women, decreased fetal viability, intra-uterine growth retardation, low birth weight and infant mortality. The physiopathology of malaria in pregnancy is difficult to scrutinize and attempts were made in the past to use animal models for pregnancy malaria studies. Here, we describe a comprehensive mouse experimental model that recapitulates many of the pathological and clinical features typical of human severe malaria in pregnancy. We used P. berghei ANKA-GFP infection during pregnancy to evoke a prominent inflammatory response in the placenta that entails CD11b mononuclear infiltration, up-regulation of MIP-1 alpha chemokine and is associated with marked reduction of placental vascular spaces. Placenta pathology was associated with decreased fetal viability, intra-uterine growth retardation, gross post-natal growth impairment and increased disease severity in pregnant females. Moreover, we provide evidence that CSA and HA, known to mediate P. falciparum adhesion to human placenta, are also involved in mouse placental malaria infection. We propose that reduction of maternal blood flow in the placenta is a key pathogenic factor in murine pregnancy malaria and we hypothesize that exacerbated innate inflammatory responses to Plasmodium infected red blood cells trigger severe placenta pathology. This experimental model provides an opportunity to identify cell and molecular components of severe PAM pathogenesis and to investigate the inflammatory response that leads to the observed fetal and placental blood circulation abnormalities.Rita NeresClaudio R F MarinhoLígia A GonçalvesManuela Beirão CatarinoCarlos Penha-GonçalvesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 2, p e1608 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rita Neres Claudio R F Marinho Lígia A Gonçalves Manuela Beirão Catarino Carlos Penha-Gonçalves Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
description	Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that include increased disease severity in pregnant women, decreased fetal viability, intra-uterine growth retardation, low birth weight and infant mortality. The physiopathology of malaria in pregnancy is difficult to scrutinize and attempts were made in the past to use animal models for pregnancy malaria studies. Here, we describe a comprehensive mouse experimental model that recapitulates many of the pathological and clinical features typical of human severe malaria in pregnancy. We used P. berghei ANKA-GFP infection during pregnancy to evoke a prominent inflammatory response in the placenta that entails CD11b mononuclear infiltration, up-regulation of MIP-1 alpha chemokine and is associated with marked reduction of placental vascular spaces. Placenta pathology was associated with decreased fetal viability, intra-uterine growth retardation, gross post-natal growth impairment and increased disease severity in pregnant females. Moreover, we provide evidence that CSA and HA, known to mediate P. falciparum adhesion to human placenta, are also involved in mouse placental malaria infection. We propose that reduction of maternal blood flow in the placenta is a key pathogenic factor in murine pregnancy malaria and we hypothesize that exacerbated innate inflammatory responses to Plasmodium infected red blood cells trigger severe placenta pathology. This experimental model provides an opportunity to identify cell and molecular components of severe PAM pathogenesis and to investigate the inflammatory response that leads to the observed fetal and placental blood circulation abnormalities.
format	article
author	Rita Neres Claudio R F Marinho Lígia A Gonçalves Manuela Beirão Catarino Carlos Penha-Gonçalves
author_facet	Rita Neres Claudio R F Marinho Lígia A Gonçalves Manuela Beirão Catarino Carlos Penha-Gonçalves
author_sort	Rita Neres
title	Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
title_short	Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
title_full	Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
title_fullStr	Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
title_full_unstemmed	Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.
title_sort	pregnancy outcome and placenta pathology in plasmodium berghei anka infected mice reproduce the pathogenesis of severe malaria in pregnant women.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/e40648fa3f1244e0b3e7e7cc308f7a84
work_keys_str_mv	AT ritaneres pregnancyoutcomeandplacentapathologyinplasmodiumbergheiankainfectedmicereproducethepathogenesisofseveremalariainpregnantwomen AT claudiorfmarinho pregnancyoutcomeandplacentapathologyinplasmodiumbergheiankainfectedmicereproducethepathogenesisofseveremalariainpregnantwomen AT ligiaagoncalves pregnancyoutcomeandplacentapathologyinplasmodiumbergheiankainfectedmicereproducethepathogenesisofseveremalariainpregnantwomen AT manuelabeiraocatarino pregnancyoutcomeandplacentapathologyinplasmodiumbergheiankainfectedmicereproducethepathogenesisofseveremalariainpregnantwomen AT carlospenhagoncalves pregnancyoutcomeandplacentapathologyinplasmodiumbergheiankainfectedmicereproducethepathogenesisofseveremalariainpregnantwomen
_version_	1718414016324304896

Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.

Ejemplares similares