Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2 Nme alone and in complex with Cas9.

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Autores principales:	Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima Hidalgo-Reyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4066aeabab14fe3b824f6c38d4f8d8d
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spelling	oai:doaj.org-article:e4066aeabab14fe3b824f6c38d4f8d8d2021-12-02T17:01:54ZInhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC210.1038/s41467-019-10577-32041-1723https://doaj.org/article/e4066aeabab14fe3b824f6c38d4f8d8d2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10577-3https://doaj.org/toc/2041-1723Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2 Nme alone and in complex with Cas9.Annoj ThavalingamZhi ChengBianca GarciaXue HuangMegha ShahWei SunMin WangLucas HarringtonSungwon HwangYurima Hidalgo-ReyesErik J. SontheimerJennifer DoudnaAlan R. DavidsonTrevor F. MoraesYanli WangKaren L. MaxwellNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annoj Thavalingam Zhi Cheng Bianca Garcia Xue Huang Megha Shah Wei Sun Min Wang Lucas Harrington Sungwon Hwang Yurima Hidalgo-Reyes Erik J. Sontheimer Jennifer Doudna Alan R. Davidson Trevor F. Moraes Yanli Wang Karen L. Maxwell Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
description	Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2 Nme alone and in complex with Cas9.
format	article
author	Annoj Thavalingam Zhi Cheng Bianca Garcia Xue Huang Megha Shah Wei Sun Min Wang Lucas Harrington Sungwon Hwang Yurima Hidalgo-Reyes Erik J. Sontheimer Jennifer Doudna Alan R. Davidson Trevor F. Moraes Yanli Wang Karen L. Maxwell
author_facet	Annoj Thavalingam Zhi Cheng Bianca Garcia Xue Huang Megha Shah Wei Sun Min Wang Lucas Harrington Sungwon Hwang Yurima Hidalgo-Reyes Erik J. Sontheimer Jennifer Doudna Alan R. Davidson Trevor F. Moraes Yanli Wang Karen L. Maxwell
author_sort	Annoj Thavalingam
title	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
title_short	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
title_full	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
title_fullStr	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
title_full_unstemmed	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
title_sort	inhibition of crispr-cas9 ribonucleoprotein complex assembly by anti-crispr acriic2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4066aeabab14fe3b824f6c38d4f8d8d
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Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

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