Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.

The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was perfo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Manal Khalifé, Rachel Young, Bruno Passet, Sophie Halliez, Marthe Vilotte, Florence Jaffrezic, Sylvain Marthey, Vincent Béringue, Daniel Vaiman, Fabienne Le Provost, Hubert Laude, Jean-Luc Vilotte
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4072883fbd4430fac40853cb07c56e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4072883fbd4430fac40853cb07c56e8
record_format	dspace
spelling	oai:doaj.org-article:e4072883fbd4430fac40853cb07c56e82021-11-18T06:47:58ZTranscriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.1932-620310.1371/journal.pone.0023253https://doaj.org/article/e4072883fbd4430fac40853cb07c56e82011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858045/?tool=EBIhttps://doaj.org/toc/1932-6203The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.Manal KhaliféRachel YoungBruno PassetSophie HalliezMarthe VilotteFlorence JaffrezicSylvain MartheyVincent BéringueDaniel VaimanFabienne Le ProvostHubert LaudeJean-Luc VilottePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23253 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manal Khalifé Rachel Young Bruno Passet Sophie Halliez Marthe Vilotte Florence Jaffrezic Sylvain Marthey Vincent Béringue Daniel Vaiman Fabienne Le Provost Hubert Laude Jean-Luc Vilotte Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
description	The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.
format	article
author	Manal Khalifé Rachel Young Bruno Passet Sophie Halliez Marthe Vilotte Florence Jaffrezic Sylvain Marthey Vincent Béringue Daniel Vaiman Fabienne Le Provost Hubert Laude Jean-Luc Vilotte
author_facet	Manal Khalifé Rachel Young Bruno Passet Sophie Halliez Marthe Vilotte Florence Jaffrezic Sylvain Marthey Vincent Béringue Daniel Vaiman Fabienne Le Provost Hubert Laude Jean-Luc Vilotte
author_sort	Manal Khalifé
title	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
title_short	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
title_full	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
title_fullStr	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
title_full_unstemmed	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
title_sort	transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e4072883fbd4430fac40853cb07c56e8
work_keys_str_mv	AT manalkhalife transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT rachelyoung transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT brunopasset transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT sophiehalliez transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT marthevilotte transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT florencejaffrezic transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT sylvainmarthey transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT vincentberingue transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT danielvaiman transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT fabienneleprovost transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT hubertlaude transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis AT jeanlucvilotte transcriptomicanalysisbringsnewinsightintothebiologicalroleoftheprionproteinduringmouseembryogenesis
_version_	1718424387255795712

Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.

Ejemplares similares