Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog

Abstract A 3‐year‐old spayed female English Springer Spaniel was presented twice 4 months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emmanuelle Marie Butty, Shelley Hahn, Mary Anna Labato
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bladder carcinoma in situ urology urothelial carcinoma Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/e4072b2409ea45e0ab82fdb97db5a969
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4072b2409ea45e0ab82fdb97db5a969
record_format	dspace
spelling	oai:doaj.org-article:e4072b2409ea45e0ab82fdb97db5a9692021-11-30T17:01:05ZPresumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog1939-16760891-664010.1111/jvim.16107https://doaj.org/article/e4072b2409ea45e0ab82fdb97db5a9692021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16107https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract A 3‐year‐old spayed female English Springer Spaniel was presented twice 4 months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples indicated lymphoplasmacytic cystitis and the second polypoid cystitis. The dog was represented 8 months later for recurrent clinical signs despite medical management. Although the ultrasound examination showed stable disease, repeat cystoscopic biopsy identified transitional cell carcinoma (TCC), confirmed on tissue removed by partial cystectomy. No BRAF mutation was ever detected in urine or tissue samples. To our knowledge, this case represents the first report of presumptive malignant transformation of polypoid cystitis into an apical TCC in a dog. Dogs with polypoid cystitis should be followed closely and surgical management considered if rapid resolution is not achieved with medical management.Emmanuelle Marie ButtyShelley HahnMary Anna LabatoWileyarticlebladdercarcinoma in situurologyurothelial carcinomaVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1551-1557 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder carcinoma in situ urology urothelial carcinoma Veterinary medicine SF600-1100
spellingShingle	bladder carcinoma in situ urology urothelial carcinoma Veterinary medicine SF600-1100 Emmanuelle Marie Butty Shelley Hahn Mary Anna Labato Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
description	Abstract A 3‐year‐old spayed female English Springer Spaniel was presented twice 4 months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples indicated lymphoplasmacytic cystitis and the second polypoid cystitis. The dog was represented 8 months later for recurrent clinical signs despite medical management. Although the ultrasound examination showed stable disease, repeat cystoscopic biopsy identified transitional cell carcinoma (TCC), confirmed on tissue removed by partial cystectomy. No BRAF mutation was ever detected in urine or tissue samples. To our knowledge, this case represents the first report of presumptive malignant transformation of polypoid cystitis into an apical TCC in a dog. Dogs with polypoid cystitis should be followed closely and surgical management considered if rapid resolution is not achieved with medical management.
format	article
author	Emmanuelle Marie Butty Shelley Hahn Mary Anna Labato
author_facet	Emmanuelle Marie Butty Shelley Hahn Mary Anna Labato
author_sort	Emmanuelle Marie Butty
title	Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
title_short	Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
title_full	Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
title_fullStr	Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
title_full_unstemmed	Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog
title_sort	presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without braf mutation in a young female dog
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e4072b2409ea45e0ab82fdb97db5a969
work_keys_str_mv	AT emmanuellemariebutty presumptivemalignanttransformationofchronicpolypoidcystitisintoanapicaltransitionalcellcarcinomawithoutbrafmutationinayoungfemaledog AT shelleyhahn presumptivemalignanttransformationofchronicpolypoidcystitisintoanapicaltransitionalcellcarcinomawithoutbrafmutationinayoungfemaledog AT maryannalabato presumptivemalignanttransformationofchronicpolypoidcystitisintoanapicaltransitionalcellcarcinomawithoutbrafmutationinayoungfemaledog
_version_	1718406476139069440

Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog

Ejemplares similares