Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans

Abstract The relative contribution of lean mass and fat mass on bone health is inconclusive. We investigated the relative contributions of lean and fat masses on fragility fracture risk in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung beginning in 20...

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Autores principales:	Jung Hee Kim, A. Ram Hong, Hyung Jin Choi, Eu Jeong Ku, Nam H. Cho, Chan Soo Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e409c735080b42b39a058756790c267d
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spelling	oai:doaj.org-article:e409c735080b42b39a058756790c267d2021-12-02T12:30:45ZSex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans10.1038/s41598-017-06386-72045-2322https://doaj.org/article/e409c735080b42b39a058756790c267d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06386-7https://doaj.org/toc/2045-2322Abstract The relative contribution of lean mass and fat mass on bone health is inconclusive. We investigated the relative contributions of lean and fat masses on fragility fracture risk in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung beginning in 2001, which included 2,189 men and 2,625 women over 40 years old. Study subjects were classified into the following four groups according to lean mass (LM)/height2 and percentage fat mass (PF). Clinical fragility fracture events were assessed at baseline and biennially using self-reported questionnaires. During a median follow-up of 9.4 years, 77 (3.5%) men and 203 (7.7%) women experienced at least one incident fracture. In Cox proportional hazard models, men with low LM under normal and high PF had a 2.16 and 2.59- fold higher risk for fragility fractures than normal ones even after adjusting for covariates. However, in women, low LM or high FM was not associated with fracture risk. We demonstrated sex-based differences in the association of body composition and incident fracture risk in Koreans aged over 40 years during a 10-year follow-up duration. Maintaining muscle mass in men is vital to maintaining bone health and preventing fragility fractures in Koreans.Jung Hee KimA. Ram HongHyung Jin ChoiEu Jeong KuNam H. ChoChan Soo ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung Hee Kim A. Ram Hong Hyung Jin Choi Eu Jeong Ku Nam H. Cho Chan Soo Shin Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
description	Abstract The relative contribution of lean mass and fat mass on bone health is inconclusive. We investigated the relative contributions of lean and fat masses on fragility fracture risk in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung beginning in 2001, which included 2,189 men and 2,625 women over 40 years old. Study subjects were classified into the following four groups according to lean mass (LM)/height2 and percentage fat mass (PF). Clinical fragility fracture events were assessed at baseline and biennially using self-reported questionnaires. During a median follow-up of 9.4 years, 77 (3.5%) men and 203 (7.7%) women experienced at least one incident fracture. In Cox proportional hazard models, men with low LM under normal and high PF had a 2.16 and 2.59- fold higher risk for fragility fractures than normal ones even after adjusting for covariates. However, in women, low LM or high FM was not associated with fracture risk. We demonstrated sex-based differences in the association of body composition and incident fracture risk in Koreans aged over 40 years during a 10-year follow-up duration. Maintaining muscle mass in men is vital to maintaining bone health and preventing fragility fractures in Koreans.
format	article
author	Jung Hee Kim A. Ram Hong Hyung Jin Choi Eu Jeong Ku Nam H. Cho Chan Soo Shin
author_facet	Jung Hee Kim A. Ram Hong Hyung Jin Choi Eu Jeong Ku Nam H. Cho Chan Soo Shin
author_sort	Jung Hee Kim
title	Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
title_short	Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
title_full	Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
title_fullStr	Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
title_full_unstemmed	Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans
title_sort	sex-based differences in the association between body composition and incident fracture risk in koreans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e409c735080b42b39a058756790c267d
work_keys_str_mv	AT jungheekim sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans AT aramhong sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans AT hyungjinchoi sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans AT eujeongku sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans AT namhcho sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans AT chansooshin sexbaseddifferencesintheassociationbetweenbodycompositionandincidentfractureriskinkoreans
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Sex-based Differences in the Association between Body Composition and Incident Fracture Risk in Koreans

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