Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy.

Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy.

<h4>Background</h4>Low expression thymidylate synthase (TS) polymorphism has been associated with increased stavudine triphosphate intracellular (d4T-TP) levels and the lipodystrophy syndrome. The use of d4T has been associated with acute pancreatitis and peripheral neuropathy. However,...

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Autores principales: Pere Domingo, Maria del Carmen Cabeza, Ferran Torres, Juliana Salazar, Maria del Mar Gutierrez, Maria Gracia Mateo, Esteban Martínez, Joan Carles Domingo, Irene Fernandez, Francesc Villarroya, Esteban Ribera, Francesc Vidal, Montserrat Baiget
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e40d6c4aa22f4e038fe92bb0db00f7c6
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