Network effects of risk behavior change following prophylactic interventions.

We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where "less (intervention) is more (effective)." Our model captures the distinction between one- and two-sided risk behavior...

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Autores principales:	Rajmohan Rajaraman, Zhifeng Sun, Ravi Sundaram, Anil Kumar S Vullikanti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e40e4396c9044971bd9181ef07fed54b
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spelling	oai:doaj.org-article:e40e4396c9044971bd9181ef07fed54b2021-11-18T09:01:46ZNetwork effects of risk behavior change following prophylactic interventions.1932-620310.1371/journal.pone.0064653https://doaj.org/article/e40e4396c9044971bd9181ef07fed54b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936290/?tool=EBIhttps://doaj.org/toc/1932-6203We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where "less (intervention) is more (effective)." Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the "sidedness" of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the "sidedness," targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage.Rajmohan RajaramanZhifeng SunRavi SundaramAnil Kumar S VullikantiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e64653 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajmohan Rajaraman Zhifeng Sun Ravi Sundaram Anil Kumar S Vullikanti Network effects of risk behavior change following prophylactic interventions.
description	We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where "less (intervention) is more (effective)." Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the "sidedness" of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the "sidedness," targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage.
format	article
author	Rajmohan Rajaraman Zhifeng Sun Ravi Sundaram Anil Kumar S Vullikanti
author_facet	Rajmohan Rajaraman Zhifeng Sun Ravi Sundaram Anil Kumar S Vullikanti
author_sort	Rajmohan Rajaraman
title	Network effects of risk behavior change following prophylactic interventions.
title_short	Network effects of risk behavior change following prophylactic interventions.
title_full	Network effects of risk behavior change following prophylactic interventions.
title_fullStr	Network effects of risk behavior change following prophylactic interventions.
title_full_unstemmed	Network effects of risk behavior change following prophylactic interventions.
title_sort	network effects of risk behavior change following prophylactic interventions.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e40e4396c9044971bd9181ef07fed54b
work_keys_str_mv	AT rajmohanrajaraman networkeffectsofriskbehaviorchangefollowingprophylacticinterventions AT zhifengsun networkeffectsofriskbehaviorchangefollowingprophylacticinterventions AT ravisundaram networkeffectsofriskbehaviorchangefollowingprophylacticinterventions AT anilkumarsvullikanti networkeffectsofriskbehaviorchangefollowingprophylacticinterventions
_version_	1718421055445401600

Network effects of risk behavior change following prophylactic interventions.

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