Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB

Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarp...

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Autores principales:	Su Jung Hwang, Won Keun Oh, Ho-Young Lee, Hyo-Jong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Pterocarpan Cristacarpin Erythrabyssin I Inflammation Uveitis Ninjurin1 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e40f51c9605d46bf8ed55ee495ef3d61
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spelling	oai:doaj.org-article:e40f51c9605d46bf8ed55ee495ef3d612021-12-04T04:33:05ZPreventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB0753-332210.1016/j.biopha.2021.112474https://doaj.org/article/e40f51c9605d46bf8ed55ee495ef3d612022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012609https://doaj.org/toc/0753-3322Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. In the non-toxic concentration range (from 20 to 100 μM), cristacarpin suppressed pro-inflammatory mediators such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, while stimulating anti-inflammatory mediators such as IL-4 and IL-10 in LPS-stimulated RAW 264.7 cells and uveitis mouse models. Cristacarpin decreased cell adhesion of macrophages through downregulation of the expression of Ninjurin1 and matrix metalloproteinases. Furthermore, cristacarpin reduced macrophage migration in zebrafish embryos in vivo. Cristacarpin also increased cytosolic levels of inhibitor of nuclear factor-κB and suppressed the nuclear translocation of nuclear factor κ-light-chain-enhancer of activated B cells. Collectively, our results suggest that cristacarpin is a potential therapeutic candidate for developing ocular anti-inflammatory drugs.Su Jung HwangWon Keun OhHo-Young LeeHyo-Jong LeeElsevierarticlePterocarpanCristacarpinErythrabyssin IInflammationUveitisNinjurin1Therapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112474- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pterocarpan Cristacarpin Erythrabyssin I Inflammation Uveitis Ninjurin1 Therapeutics. Pharmacology RM1-950
spellingShingle	Pterocarpan Cristacarpin Erythrabyssin I Inflammation Uveitis Ninjurin1 Therapeutics. Pharmacology RM1-950 Su Jung Hwang Won Keun Oh Ho-Young Lee Hyo-Jong Lee Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
description	Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. In the non-toxic concentration range (from 20 to 100 μM), cristacarpin suppressed pro-inflammatory mediators such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, while stimulating anti-inflammatory mediators such as IL-4 and IL-10 in LPS-stimulated RAW 264.7 cells and uveitis mouse models. Cristacarpin decreased cell adhesion of macrophages through downregulation of the expression of Ninjurin1 and matrix metalloproteinases. Furthermore, cristacarpin reduced macrophage migration in zebrafish embryos in vivo. Cristacarpin also increased cytosolic levels of inhibitor of nuclear factor-κB and suppressed the nuclear translocation of nuclear factor κ-light-chain-enhancer of activated B cells. Collectively, our results suggest that cristacarpin is a potential therapeutic candidate for developing ocular anti-inflammatory drugs.
format	article
author	Su Jung Hwang Won Keun Oh Ho-Young Lee Hyo-Jong Lee
author_facet	Su Jung Hwang Won Keun Oh Ho-Young Lee Hyo-Jong Lee
author_sort	Su Jung Hwang
title	Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
title_short	Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
title_full	Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
title_fullStr	Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
title_full_unstemmed	Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB
title_sort	preventive effects of cristacarpin on experimentally induced uveitis by targeting nf-κb
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/e40f51c9605d46bf8ed55ee495ef3d61
work_keys_str_mv	AT sujunghwang preventiveeffectsofcristacarpinonexperimentallyinduceduveitisbytargetingnfkb AT wonkeunoh preventiveeffectsofcristacarpinonexperimentallyinduceduveitisbytargetingnfkb AT hoyounglee preventiveeffectsofcristacarpinonexperimentallyinduceduveitisbytargetingnfkb AT hyojonglee preventiveeffectsofcristacarpinonexperimentallyinduceduveitisbytargetingnfkb
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Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB

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