An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations

Genome-wide association studies (GWAS) have been very successful at identifying genetic variants influencing a large number of traits. Although the great majority of these studies have been performed in European-descent individuals, it has been recognised that including populations with differing an...

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Autores principales:	Irving Simonin-Wilmer, Pedro Orozco-del-Pino, D. Timothy Bishop, Mark M. Iles, Carla Daniela Robles-Espinoza
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	GWAS admixture ancestry PCA regression Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e40ff356c7114bd7ab62378e5e23fdf2
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id	oai:doaj.org-article:e40ff356c7114bd7ab62378e5e23fdf2
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spelling	oai:doaj.org-article:e40ff356c7114bd7ab62378e5e23fdf22021-11-05T11:17:37ZAn Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations1664-802110.3389/fgene.2021.703901https://doaj.org/article/e40ff356c7114bd7ab62378e5e23fdf22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.703901/fullhttps://doaj.org/toc/1664-8021Genome-wide association studies (GWAS) have been very successful at identifying genetic variants influencing a large number of traits. Although the great majority of these studies have been performed in European-descent individuals, it has been recognised that including populations with differing ancestries enhances the potential for identifying causal SNPs due to their differing patterns of linkage disequilibrium. However, when individuals from distinct ethnicities are included in a GWAS, it is necessary to implement a number of control steps to ensure that the identified associations are real genotype-phenotype relationships. In this Review, we discuss the analyses that are required when performing multi-ethnic studies, including methods for determining ancestry at the global and local level for sample exclusion, controlling for ancestry in association testing, and post-GWAS interrogation methods such as genomic control and meta-analysis. We hope that this overview provides a primer for those researchers interested in including distinct populations in their studies.Irving Simonin-WilmerPedro Orozco-del-PinoD. Timothy BishopMark M. IlesCarla Daniela Robles-EspinozaCarla Daniela Robles-EspinozaFrontiers Media S.A.articleGWASadmixtureancestryPCAregressionGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GWAS admixture ancestry PCA regression Genetics QH426-470
spellingShingle	GWAS admixture ancestry PCA regression Genetics QH426-470 Irving Simonin-Wilmer Pedro Orozco-del-Pino D. Timothy Bishop Mark M. Iles Carla Daniela Robles-Espinoza Carla Daniela Robles-Espinoza An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
description	Genome-wide association studies (GWAS) have been very successful at identifying genetic variants influencing a large number of traits. Although the great majority of these studies have been performed in European-descent individuals, it has been recognised that including populations with differing ancestries enhances the potential for identifying causal SNPs due to their differing patterns of linkage disequilibrium. However, when individuals from distinct ethnicities are included in a GWAS, it is necessary to implement a number of control steps to ensure that the identified associations are real genotype-phenotype relationships. In this Review, we discuss the analyses that are required when performing multi-ethnic studies, including methods for determining ancestry at the global and local level for sample exclusion, controlling for ancestry in association testing, and post-GWAS interrogation methods such as genomic control and meta-analysis. We hope that this overview provides a primer for those researchers interested in including distinct populations in their studies.
format	article
author	Irving Simonin-Wilmer Pedro Orozco-del-Pino D. Timothy Bishop Mark M. Iles Carla Daniela Robles-Espinoza Carla Daniela Robles-Espinoza
author_facet	Irving Simonin-Wilmer Pedro Orozco-del-Pino D. Timothy Bishop Mark M. Iles Carla Daniela Robles-Espinoza Carla Daniela Robles-Espinoza
author_sort	Irving Simonin-Wilmer
title	An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
title_short	An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
title_full	An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
title_fullStr	An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
title_full_unstemmed	An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations
title_sort	overview of strategies for detecting genotype-phenotype associations across ancestrally diverse populations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e40ff356c7114bd7ab62378e5e23fdf2
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An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations

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