Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Hepatocellular carcinoma (HCC) is a malignant tumor with the highest mortality rate in the world, and hepatitis B virus (HBV) plays an important role in its development. Long noncoding RNA (lncRNA) is highly related to the inactivation of tumor suppressor genes and the activation of oncogenes in HCC...

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Autores principales:	Xueke Wang, Meisong Kang, Chun Liu, Ting Lin, Xiao Han, Xiwen Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNA hepatocellular carcinoma hepatitis B virus HBx protein microRNA Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e412ceb8ff114f73893c7aaf4225a54c
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spelling	oai:doaj.org-article:e412ceb8ff114f73893c7aaf4225a54c2021-11-18T05:09:32ZCurrent State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer2235-298810.3389/fcimb.2021.714895https://doaj.org/article/e412ceb8ff114f73893c7aaf4225a54c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.714895/fullhttps://doaj.org/toc/2235-2988Hepatocellular carcinoma (HCC) is a malignant tumor with the highest mortality rate in the world, and hepatitis B virus (HBV) plays an important role in its development. Long noncoding RNA (lncRNA) is highly related to the inactivation of tumor suppressor genes and the activation of oncogenes in HCC. Researchers have used high-throughput sequencing technology to identify many noncoding transcripts related to the development of HCC and have studied the interaction between these transcripts and DNA, RNA, or protein to determine the relevant mechanism in the development of HCC. In general, the research on lncRNA represents a new field of cancer research, and the imbalance in lncRNA plays an pivotal role in the occurrence of liver cancer. In this review, we summarize some of the dysfunctional lncRNAs in human HCC associated with HBV infection. Their regulatory pathways, functions, and potential molecular mechanisms in the occurrence and development of HCC are discussed.Xueke WangMeisong KangChun LiuTing LinXiao HanXiwen JiangFrontiers Media S.A.articlelncRNAhepatocellular carcinomahepatitis B virusHBx proteinmicroRNAMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNA hepatocellular carcinoma hepatitis B virus HBx protein microRNA Microbiology QR1-502
spellingShingle	lncRNA hepatocellular carcinoma hepatitis B virus HBx protein microRNA Microbiology QR1-502 Xueke Wang Meisong Kang Chun Liu Ting Lin Xiao Han Xiwen Jiang Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
description	Hepatocellular carcinoma (HCC) is a malignant tumor with the highest mortality rate in the world, and hepatitis B virus (HBV) plays an important role in its development. Long noncoding RNA (lncRNA) is highly related to the inactivation of tumor suppressor genes and the activation of oncogenes in HCC. Researchers have used high-throughput sequencing technology to identify many noncoding transcripts related to the development of HCC and have studied the interaction between these transcripts and DNA, RNA, or protein to determine the relevant mechanism in the development of HCC. In general, the research on lncRNA represents a new field of cancer research, and the imbalance in lncRNA plays an pivotal role in the occurrence of liver cancer. In this review, we summarize some of the dysfunctional lncRNAs in human HCC associated with HBV infection. Their regulatory pathways, functions, and potential molecular mechanisms in the occurrence and development of HCC are discussed.
format	article
author	Xueke Wang Meisong Kang Chun Liu Ting Lin Xiao Han Xiwen Jiang
author_facet	Xueke Wang Meisong Kang Chun Liu Ting Lin Xiao Han Xiwen Jiang
author_sort	Xueke Wang
title	Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
title_short	Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
title_full	Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
title_fullStr	Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
title_full_unstemmed	Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer
title_sort	current state and progress of research on the role of lncrna in hbv-related liver cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e412ceb8ff114f73893c7aaf4225a54c
work_keys_str_mv	AT xuekewang currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer AT meisongkang currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer AT chunliu currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer AT tinglin currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer AT xiaohan currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer AT xiwenjiang currentstateandprogressofresearchontheroleoflncrnainhbvrelatedlivercancer
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Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

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