Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts

Aim. To determine the association of the MMP-9 genetic polymorphism with the risk of developing endometrioid ovarian cysts (ECC). Materials and methods. 55 women aged 19 to 47 were examined. 27 women underwent surgery for ECC (group 1). The control (group 2) consisted of 28 patients without endom...

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Autores principales:	Svetlana O. Dubrovina, Iuliia D. Berlim, Marina A. Vovkochina, Sergei V. Mordanov, Anna D. Aleksandrina
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	endometriotic cysts matrix metalloproteinases genetic polymorphism Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/e412ec5e40b04ee587a84217177c4d46
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spelling	oai:doaj.org-article:e412ec5e40b04ee587a84217177c4d462021-12-02T19:22:24ZEstimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts2079-56962079-583110.26442/20795696.2021.5.201057https://doaj.org/article/e412ec5e40b04ee587a84217177c4d462021-11-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/88598/66776https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To determine the association of the MMP-9 genetic polymorphism with the risk of developing endometrioid ovarian cysts (ECC). Materials and methods. 55 women aged 19 to 47 were examined. 27 women underwent surgery for ECC (group 1). The control (group 2) consisted of 28 patients without endometriosis and operated because of tubal infertility. Single nucleotide polymorphism was investigated. Genotyping was performed by restriction fragment length polymorphism analysis. Results. We did not find statistically significant differences between the group of patients with ECF and the control group in terms of age 29.0 (25.95; 33.1), 34.5 (29.3; 37.0); p0.05, body mass index 21.2 (19.8; 22.6), 21.95 (20.4; 23.9), p0.05, age of menarche onset 13.0 (12.95; 14.0), 13.0 (12.0; 14.0), p0.05, duration of menstrual bleeding 5.0 (5.0; 5.0), 5.0 (5.0; 6.0), p0.05 for the 1st and 2nd groups, respectively, also dysmenorrhea (2 0.019; p=0.8918), the number of births (2 3.441; p=0.3285) and abortions (2 2.822; p=0.0930) in anamnesis. The frequencies of all studied genotypes of metalloproteinase MMP-9 C (1562) T of the MMP9 gene in the group of patients with ECF and the control group are in HardyWeinberg equilibrium (p=0.99, p=0.43 for 1 and 2 group) which excludes differences in the distribution of genotype frequencies of polymorphic loci of MMP9 genes in the group of patients with ECF and the control group. However, the result could be influenced by the severity of the disease and the size of the study groups. Conclusion. Given the undoubted role of matrix metalloproteinases in the pathogenesis of genital endometriosis, further studies with large samples in various populations are needed.Svetlana O. DubrovinaIuliia D. BerlimMarina A. VovkochinaSergei V. MordanovAnna D. AleksandrinaIP Berlin A.V. articleendometriotic cystsmatrix metalloproteinasesgenetic polymorphismGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 5, Pp 407-412 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	endometriotic cysts matrix metalloproteinases genetic polymorphism Gynecology and obstetrics RG1-991
spellingShingle	endometriotic cysts matrix metalloproteinases genetic polymorphism Gynecology and obstetrics RG1-991 Svetlana O. Dubrovina Iuliia D. Berlim Marina A. Vovkochina Sergei V. Mordanov Anna D. Aleksandrina Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
description	Aim. To determine the association of the MMP-9 genetic polymorphism with the risk of developing endometrioid ovarian cysts (ECC). Materials and methods. 55 women aged 19 to 47 were examined. 27 women underwent surgery for ECC (group 1). The control (group 2) consisted of 28 patients without endometriosis and operated because of tubal infertility. Single nucleotide polymorphism was investigated. Genotyping was performed by restriction fragment length polymorphism analysis. Results. We did not find statistically significant differences between the group of patients with ECF and the control group in terms of age 29.0 (25.95; 33.1), 34.5 (29.3; 37.0); p0.05, body mass index 21.2 (19.8; 22.6), 21.95 (20.4; 23.9), p0.05, age of menarche onset 13.0 (12.95; 14.0), 13.0 (12.0; 14.0), p0.05, duration of menstrual bleeding 5.0 (5.0; 5.0), 5.0 (5.0; 6.0), p0.05 for the 1st and 2nd groups, respectively, also dysmenorrhea (2 0.019; p=0.8918), the number of births (2 3.441; p=0.3285) and abortions (2 2.822; p=0.0930) in anamnesis. The frequencies of all studied genotypes of metalloproteinase MMP-9 C (1562) T of the MMP9 gene in the group of patients with ECF and the control group are in HardyWeinberg equilibrium (p=0.99, p=0.43 for 1 and 2 group) which excludes differences in the distribution of genotype frequencies of polymorphic loci of MMP9 genes in the group of patients with ECF and the control group. However, the result could be influenced by the severity of the disease and the size of the study groups. Conclusion. Given the undoubted role of matrix metalloproteinases in the pathogenesis of genital endometriosis, further studies with large samples in various populations are needed.
format	article
author	Svetlana O. Dubrovina Iuliia D. Berlim Marina A. Vovkochina Sergei V. Mordanov Anna D. Aleksandrina
author_facet	Svetlana O. Dubrovina Iuliia D. Berlim Marina A. Vovkochina Sergei V. Mordanov Anna D. Aleksandrina
author_sort	Svetlana O. Dubrovina
title	Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
title_short	Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
title_full	Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
title_fullStr	Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
title_full_unstemmed	Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
title_sort	estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/e412ec5e40b04ee587a84217177c4d46
work_keys_str_mv	AT svetlanaodubrovina estimationofthepolymorphismofmatrixmetalproteinasegenesinpatientswithendometrioidovariancysts AT iuliiadberlim estimationofthepolymorphismofmatrixmetalproteinasegenesinpatientswithendometrioidovariancysts AT marinaavovkochina estimationofthepolymorphismofmatrixmetalproteinasegenesinpatientswithendometrioidovariancysts AT sergeivmordanov estimationofthepolymorphismofmatrixmetalproteinasegenesinpatientswithendometrioidovariancysts AT annadaleksandrina estimationofthepolymorphismofmatrixmetalproteinasegenesinpatientswithendometrioidovariancysts
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Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts

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