Clot waveform of APTT has abnormal patterns in subjects with COVID-19

Abstract In Coronavirus disease 2019 (COVID-19) subjects, recent evidence suggests the presence of unique coagulation abnormalities. In this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 subjects. We analyzed the second derivative of...

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Autores principales:	Takuya Shimura, Makoto Kurano, Yoshiaki Kanno, Mahoko Ikeda, Koh Okamoto, Daisuke Jubishi, Sohei Harada, Shu Okugawa, Kyoji Moriya, Yutaka Yatomi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e414000f3fe743429396668c68073775
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spelling	oai:doaj.org-article:e414000f3fe743429396668c680737752021-12-02T15:54:09ZClot waveform of APTT has abnormal patterns in subjects with COVID-1910.1038/s41598-021-84776-82045-2322https://doaj.org/article/e414000f3fe743429396668c680737752021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84776-8https://doaj.org/toc/2045-2322Abstract In Coronavirus disease 2019 (COVID-19) subjects, recent evidence suggests the presence of unique coagulation abnormalities. In this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 subjects. We analyzed the second derivative of the absorbance in routine APTT tests performed using an ACL-TOP system. We observed high frequencies of abnormal patterns in APTT second-derivative curves that could be classified into an early shoulder type, a late shoulder type, or a biphasic type, high maximum first-derivative and second-derivative peak levels, and a low minimum second-derivative peak level in COVID-19 subjects. These modulations were not observed in subjects with disseminated intravascular coagulation. These abnormal patterns are also observed in patients with lupus anticoagulant, hemophilia, or factor IX deficiency. The plasma fibrinogen levels might also be involved in the abnormal APTT waveforms, especially the high maximum first-derivative and second-derivative peak levels. The abnormal patterns in the APTT second-derivative curves appear with highest frequency at around 2 weeks after the onset of COVID-19 and were not associated with the severity of COVID-19. These results suggest the possible presence of a specific abnormal coagulopathy in COVID-19.Takuya ShimuraMakoto KuranoYoshiaki KannoMahoko IkedaKoh OkamotoDaisuke JubishiSohei HaradaShu OkugawaKyoji MoriyaYutaka YatomiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takuya Shimura Makoto Kurano Yoshiaki Kanno Mahoko Ikeda Koh Okamoto Daisuke Jubishi Sohei Harada Shu Okugawa Kyoji Moriya Yutaka Yatomi Clot waveform of APTT has abnormal patterns in subjects with COVID-19
description	Abstract In Coronavirus disease 2019 (COVID-19) subjects, recent evidence suggests the presence of unique coagulation abnormalities. In this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 subjects. We analyzed the second derivative of the absorbance in routine APTT tests performed using an ACL-TOP system. We observed high frequencies of abnormal patterns in APTT second-derivative curves that could be classified into an early shoulder type, a late shoulder type, or a biphasic type, high maximum first-derivative and second-derivative peak levels, and a low minimum second-derivative peak level in COVID-19 subjects. These modulations were not observed in subjects with disseminated intravascular coagulation. These abnormal patterns are also observed in patients with lupus anticoagulant, hemophilia, or factor IX deficiency. The plasma fibrinogen levels might also be involved in the abnormal APTT waveforms, especially the high maximum first-derivative and second-derivative peak levels. The abnormal patterns in the APTT second-derivative curves appear with highest frequency at around 2 weeks after the onset of COVID-19 and were not associated with the severity of COVID-19. These results suggest the possible presence of a specific abnormal coagulopathy in COVID-19.
format	article
author	Takuya Shimura Makoto Kurano Yoshiaki Kanno Mahoko Ikeda Koh Okamoto Daisuke Jubishi Sohei Harada Shu Okugawa Kyoji Moriya Yutaka Yatomi
author_facet	Takuya Shimura Makoto Kurano Yoshiaki Kanno Mahoko Ikeda Koh Okamoto Daisuke Jubishi Sohei Harada Shu Okugawa Kyoji Moriya Yutaka Yatomi
author_sort	Takuya Shimura
title	Clot waveform of APTT has abnormal patterns in subjects with COVID-19
title_short	Clot waveform of APTT has abnormal patterns in subjects with COVID-19
title_full	Clot waveform of APTT has abnormal patterns in subjects with COVID-19
title_fullStr	Clot waveform of APTT has abnormal patterns in subjects with COVID-19
title_full_unstemmed	Clot waveform of APTT has abnormal patterns in subjects with COVID-19
title_sort	clot waveform of aptt has abnormal patterns in subjects with covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e414000f3fe743429396668c68073775
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Clot waveform of APTT has abnormal patterns in subjects with COVID-19

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