Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint

Stomach cancer is one of the most common tumors of the gastrointestinal tract. In Russia, stomach cancer is ranked fourth in incidence among malignancies and gives ground for lung, breast and colon cancers. Although the success of PD-1/PD-L1 inhibitors application in clinical practice has been prove...

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Autores principales:	Olga V. Kovaleva, Polina A. Podlesnaya, Alexei N. Gratchev, Viktor L. Chang, Nikolai A. Ognerubov, Nikolai E. Kushlinskii
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	stomach cancer expression pd-1 pd-l1 spd-1 spd-l1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e415a458b020461d865ff5e5ab64b4b7
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spelling	oai:doaj.org-article:e415a458b020461d865ff5e5ab64b4b72021-11-30T16:55:01ZStomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint1815-14341815-144210.26442/18151434.2021.1.200749https://doaj.org/article/e415a458b020461d865ff5e5ab64b4b72021-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/55213/pdfhttps://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Stomach cancer is one of the most common tumors of the gastrointestinal tract. In Russia, stomach cancer is ranked fourth in incidence among malignancies and gives ground for lung, breast and colon cancers. Although the success of PD-1/PD-L1 inhibitors application in clinical practice has been proven in cases of many forms of malignancies, the advantages of application of these types of drugs in cases of stomach cancer has not yet been determined. The purpose of this review is to analyze modern studies concerning the clinical significance of PD-1 and PD-L1 expression in stomach tumors and to find the prospects of immunotherapy these tumors. The large number of studies are currently being described, concerning the analysis of the expression of PD-1, PD-L1 levels in tumor cells and soluble forms of these proteins sPD-1 and sPD-L1 in the serum in patients with stomach cancer. However, their clinical significance is unclear, and in many cases the predictive role of PD-L1 expression for the efficacy of immunotherapy is not yet clearly defined. Further accumulation of knowledge in this area can help to improve the efficacy of existing immunotherapy methods and to develop new predictive criteria.Olga V. KovalevaPolina A. PodlesnayaAlexei N. GratchevViktor L. ChangNikolai A. OgnerubovNikolai E. KushlinskiiIP Habib O.N.articlestomach cancerexpressionpd-1pd-l1spd-1spd-l1Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 1, Pp 122-127 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	stomach cancer expression pd-1 pd-l1 spd-1 spd-l1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	stomach cancer expression pd-1 pd-l1 spd-1 spd-l1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Olga V. Kovaleva Polina A. Podlesnaya Alexei N. Gratchev Viktor L. Chang Nikolai A. Ognerubov Nikolai E. Kushlinskii Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
description	Stomach cancer is one of the most common tumors of the gastrointestinal tract. In Russia, stomach cancer is ranked fourth in incidence among malignancies and gives ground for lung, breast and colon cancers. Although the success of PD-1/PD-L1 inhibitors application in clinical practice has been proven in cases of many forms of malignancies, the advantages of application of these types of drugs in cases of stomach cancer has not yet been determined. The purpose of this review is to analyze modern studies concerning the clinical significance of PD-1 and PD-L1 expression in stomach tumors and to find the prospects of immunotherapy these tumors. The large number of studies are currently being described, concerning the analysis of the expression of PD-1, PD-L1 levels in tumor cells and soluble forms of these proteins sPD-1 and sPD-L1 in the serum in patients with stomach cancer. However, their clinical significance is unclear, and in many cases the predictive role of PD-L1 expression for the efficacy of immunotherapy is not yet clearly defined. Further accumulation of knowledge in this area can help to improve the efficacy of existing immunotherapy methods and to develop new predictive criteria.
format	article
author	Olga V. Kovaleva Polina A. Podlesnaya Alexei N. Gratchev Viktor L. Chang Nikolai A. Ognerubov Nikolai E. Kushlinskii
author_facet	Olga V. Kovaleva Polina A. Podlesnaya Alexei N. Gratchev Viktor L. Chang Nikolai A. Ognerubov Nikolai E. Kushlinskii
author_sort	Olga V. Kovaleva
title	Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
title_short	Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
title_full	Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
title_fullStr	Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
title_full_unstemmed	Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint
title_sort	stomach cancer. clinical significance of the expression of key components of pd-1/pd-l1 immune checkpoint
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/e415a458b020461d865ff5e5ab64b4b7
work_keys_str_mv	AT olgavkovaleva stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint AT polinaapodlesnaya stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint AT alexeingratchev stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint AT viktorlchang stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint AT nikolaiaognerubov stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint AT nikolaiekushlinskii stomachcancerclinicalsignificanceoftheexpressionofkeycomponentsofpd1pdl1immunecheckpoint
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Stomach cancer. Clinical significance of the expression of key components of PD-1/PD-L1 immune checkpoint

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