VEGF promotes malaria-associated acute lung injury in mice.

The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or sever...

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Autores principales:	Sabrina Epiphanio, Marta G Campos, Ana Pamplona, Daniel Carapau, Ana C Pena, Ricardo Ataíde, Carla A A Monteiro, Nuno Félix, Artur Costa-Silva, Claudio R F Marinho, Sérgio Dias, Maria M Mota
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e418f4135e4a4940811ae94546cc159e
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spelling	oai:doaj.org-article:e418f4135e4a4940811ae94546cc159e2021-12-02T20:00:39ZVEGF promotes malaria-associated acute lung injury in mice.1553-73661553-737410.1371/journal.ppat.1000916https://doaj.org/article/e418f4135e4a4940811ae94546cc159e2010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20502682/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA). Rodent models that mimic human CM, PAM and SA syndromes have been established. Here, we show that DBA/2 mice infected with P. berghei ANKA constitute a new model for malaria-associated ALI. Up to 60% of the mice showed dyspnea, airway obstruction and hypoxemia and died between days 7 and 12 post-infection. The most common pathological findings were pleural effusion, pulmonary hemorrhage and edema, consistent with increased lung vessel permeability, while the blood-brain barrier was intact. Malaria-associated ALI correlated with high levels of circulating VEGF, produced de novo in the spleen, and its blockage led to protection of mice from this syndrome. In addition, either splenectomization or administration of the anti-inflammatory molecule carbon monoxide led to a significant reduction in the levels of sera VEGF and to protection from ALI. The similarities between the physiopathological lesions described here and the ones occurring in humans, as well as the demonstration that VEGF is a critical host factor in the onset of malaria-associated ALI in mice, not only offers important mechanistic insights into the processes underlying the pathology related with malaria but may also pave the way for interventional studies.Sabrina EpiphanioMarta G CamposAna PamplonaDaniel CarapauAna C PenaRicardo AtaídeCarla A A MonteiroNuno FélixArtur Costa-SilvaClaudio R F MarinhoSérgio DiasMaria M MotaPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 5, p e1000916 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Sabrina Epiphanio Marta G Campos Ana Pamplona Daniel Carapau Ana C Pena Ricardo Ataíde Carla A A Monteiro Nuno Félix Artur Costa-Silva Claudio R F Marinho Sérgio Dias Maria M Mota VEGF promotes malaria-associated acute lung injury in mice.
description	The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA). Rodent models that mimic human CM, PAM and SA syndromes have been established. Here, we show that DBA/2 mice infected with P. berghei ANKA constitute a new model for malaria-associated ALI. Up to 60% of the mice showed dyspnea, airway obstruction and hypoxemia and died between days 7 and 12 post-infection. The most common pathological findings were pleural effusion, pulmonary hemorrhage and edema, consistent with increased lung vessel permeability, while the blood-brain barrier was intact. Malaria-associated ALI correlated with high levels of circulating VEGF, produced de novo in the spleen, and its blockage led to protection of mice from this syndrome. In addition, either splenectomization or administration of the anti-inflammatory molecule carbon monoxide led to a significant reduction in the levels of sera VEGF and to protection from ALI. The similarities between the physiopathological lesions described here and the ones occurring in humans, as well as the demonstration that VEGF is a critical host factor in the onset of malaria-associated ALI in mice, not only offers important mechanistic insights into the processes underlying the pathology related with malaria but may also pave the way for interventional studies.
format	article
author	Sabrina Epiphanio Marta G Campos Ana Pamplona Daniel Carapau Ana C Pena Ricardo Ataíde Carla A A Monteiro Nuno Félix Artur Costa-Silva Claudio R F Marinho Sérgio Dias Maria M Mota
author_facet	Sabrina Epiphanio Marta G Campos Ana Pamplona Daniel Carapau Ana C Pena Ricardo Ataíde Carla A A Monteiro Nuno Félix Artur Costa-Silva Claudio R F Marinho Sérgio Dias Maria M Mota
author_sort	Sabrina Epiphanio
title	VEGF promotes malaria-associated acute lung injury in mice.
title_short	VEGF promotes malaria-associated acute lung injury in mice.
title_full	VEGF promotes malaria-associated acute lung injury in mice.
title_fullStr	VEGF promotes malaria-associated acute lung injury in mice.
title_full_unstemmed	VEGF promotes malaria-associated acute lung injury in mice.
title_sort	vegf promotes malaria-associated acute lung injury in mice.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e418f4135e4a4940811ae94546cc159e
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VEGF promotes malaria-associated acute lung injury in mice.

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