Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation

Abstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-li...

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Autores principales:	Ji-Hyun Jang, Sumi Shin, Hyun-Jung Kim, Jinyoung Jeong, Hyo-Eon Jin, Malav S. Desai, Seung-Wuk Lee, Sun-Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e41a54769c9145038929648220cb09d8
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spelling	oai:doaj.org-article:e41a54769c9145038929648220cb09d82021-12-02T15:05:41ZImprovement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation10.1038/s41598-018-23577-y2045-2322https://doaj.org/article/e41a54769c9145038929648220cb09d82018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23577-yhttps://doaj.org/toc/2045-2322Abstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-like polypeptides (ELPs). We investigated the effect of the ELPs on the physical properties and biocompatibility of CPC by testing ELP/CPC composites with various liquid/powder ratios. Our results show that the addition of ELPs improved the mechanical properties of the CPC, including the microhardness, compressive strength, and washout resistance. The biocompatibility of ELP/CPC composites was also comparable to that of the CPC alone. However, supplementing CPC with ELPs functionalized with octaglutamate as a hydroxyapatite binding peptide increased the setting time of the cement. With further design and modification of our biomolecules and composites, our research will lead to products with diverse applications in biology and medicine.Ji-Hyun JangSumi ShinHyun-Jung KimJinyoung JeongHyo-Eon JinMalav S. DesaiSeung-Wuk LeeSun-Young KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
description	Abstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-like polypeptides (ELPs). We investigated the effect of the ELPs on the physical properties and biocompatibility of CPC by testing ELP/CPC composites with various liquid/powder ratios. Our results show that the addition of ELPs improved the mechanical properties of the CPC, including the microhardness, compressive strength, and washout resistance. The biocompatibility of ELP/CPC composites was also comparable to that of the CPC alone. However, supplementing CPC with ELPs functionalized with octaglutamate as a hydroxyapatite binding peptide increased the setting time of the cement. With further design and modification of our biomolecules and composites, our research will lead to products with diverse applications in biology and medicine.
format	article
author	Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim
author_facet	Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim
author_sort	Ji-Hyun Jang
title	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
title_short	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
title_full	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
title_fullStr	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
title_full_unstemmed	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
title_sort	improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e41a54769c9145038929648220cb09d8
work_keys_str_mv	AT jihyunjang improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT sumishin improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT hyunjungkim improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT jinyoungjeong improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT hyoeonjin improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT malavsdesai improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT seungwuklee improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation AT sunyoungkim improvementofphysicalpropertiesofcalciumphosphatecementbyelastinlikepolypeptidesupplementation
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Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation

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