Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
<h4>Background</h4>Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previo...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/e41b45f1740b4fad90377446f5448d92 |
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| Sumario: | <h4>Background</h4>Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimation of the relationship between the -2518A/G polymorphism and cancer risk.<h4>Methodology/principal findings</h4>We performed a meta-analysis, including 4,162 cases and 5,173 controls, to evaluate the strength of the association between the -2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Overall, the results indicated that the -2518A/G polymorphism was not statistically associated with cancer risk. However, sub-group analysis revealed that individuals with GG genotypes showed an increased risk of cancer in digestive system compared with carriers of the A allele (GG vs. AA: OR = 1.43, 95%CI = 1.05-1.96, P(heterogeneity) = 0.08; GG vs.<h4>Ag/aa</h4>OR = 1.29, 95%CI = 1.02-1.64, P(heterogeneity) = 0.14). In addition, the increased risk of GG genotype was also observed in Caucasians (GG vs.<h4>Ag/aa</h4>OR = 1.81, 95%CI = 1.10-2.96, P(heterogeneity) = 0.02).<h4>Conclusion</h4>This meta-analysis suggests that the MCP-1 -2518A/G polymorphism may have some relation to digestive system cancer susceptibility or cancer development in Caucasian. Large-scale and well-designed case-control studies are needed to validate the findings. |
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