Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.

<h4>Background</h4>Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previo...

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Autores principales:	Liang-Shan Da, Ying Zhang, Shuai Zhang, Yi-Chun Qian, Qin Zhang, Feng Jiang, Lin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e41b45f1740b4fad90377446f5448d92
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spelling	oai:doaj.org-article:e41b45f1740b4fad90377446f5448d922021-11-18T08:41:20ZAssociation between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.1932-620310.1371/journal.pone.0082855https://doaj.org/article/e41b45f1740b4fad90377446f5448d922013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367564/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimation of the relationship between the -2518A/G polymorphism and cancer risk.<h4>Methodology/principal findings</h4>We performed a meta-analysis, including 4,162 cases and 5,173 controls, to evaluate the strength of the association between the -2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Overall, the results indicated that the -2518A/G polymorphism was not statistically associated with cancer risk. However, sub-group analysis revealed that individuals with GG genotypes showed an increased risk of cancer in digestive system compared with carriers of the A allele (GG vs. AA: OR = 1.43, 95%CI = 1.05-1.96, P(heterogeneity) = 0.08; GG vs.<h4>Ag/aa</h4>OR = 1.29, 95%CI = 1.02-1.64, P(heterogeneity) = 0.14). In addition, the increased risk of GG genotype was also observed in Caucasians (GG vs.<h4>Ag/aa</h4>OR = 1.81, 95%CI = 1.10-2.96, P(heterogeneity) = 0.02).<h4>Conclusion</h4>This meta-analysis suggests that the MCP-1 -2518A/G polymorphism may have some relation to digestive system cancer susceptibility or cancer development in Caucasian. Large-scale and well-designed case-control studies are needed to validate the findings.Liang-Shan DaYing ZhangShuai ZhangYi-Chun QianQin ZhangFeng JiangLin XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82855 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang-Shan Da Ying Zhang Shuai Zhang Yi-Chun Qian Qin Zhang Feng Jiang Lin Xu Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
description	<h4>Background</h4>Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimation of the relationship between the -2518A/G polymorphism and cancer risk.<h4>Methodology/principal findings</h4>We performed a meta-analysis, including 4,162 cases and 5,173 controls, to evaluate the strength of the association between the -2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Overall, the results indicated that the -2518A/G polymorphism was not statistically associated with cancer risk. However, sub-group analysis revealed that individuals with GG genotypes showed an increased risk of cancer in digestive system compared with carriers of the A allele (GG vs. AA: OR = 1.43, 95%CI = 1.05-1.96, P(heterogeneity) = 0.08; GG vs.<h4>Ag/aa</h4>OR = 1.29, 95%CI = 1.02-1.64, P(heterogeneity) = 0.14). In addition, the increased risk of GG genotype was also observed in Caucasians (GG vs.<h4>Ag/aa</h4>OR = 1.81, 95%CI = 1.10-2.96, P(heterogeneity) = 0.02).<h4>Conclusion</h4>This meta-analysis suggests that the MCP-1 -2518A/G polymorphism may have some relation to digestive system cancer susceptibility or cancer development in Caucasian. Large-scale and well-designed case-control studies are needed to validate the findings.
format	article
author	Liang-Shan Da Ying Zhang Shuai Zhang Yi-Chun Qian Qin Zhang Feng Jiang Lin Xu
author_facet	Liang-Shan Da Ying Zhang Shuai Zhang Yi-Chun Qian Qin Zhang Feng Jiang Lin Xu
author_sort	Liang-Shan Da
title	Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
title_short	Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
title_full	Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
title_fullStr	Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
title_full_unstemmed	Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.
title_sort	association between mcp-1 -2518a/g polymorphism and cancer risk: evidence from 19 case-control studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e41b45f1740b4fad90377446f5448d92
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Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 case-control studies.

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