Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

Abstract Alzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lishu Duan, Mufeng Hu, Joseph A. Tamm, Yelena Y. Grinberg, Fang Shen, Yating Chai, Hualin Xi, Lauren Gibilisco, Brinda Ravikumar, Vivek Gautam, Eric Karran, Matthew Townsend, Robert V. Talanian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e41bb5dc26104cbeac5ee6be3c197b17
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares